Zhu Y Q, Ma S P, Li B, Zheng C Y, Ma J
Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin 300222, China.
Zhonghua Yi Xue Za Zhi. 2018 Mar 13;98(10):759-762. doi: 10.3760/cma.j.issn.0376-2491.2018.10.009.
To investigate the serum level of interleukin-38 (IL-38) and its clinical significance in patients with chronic obstructive pulmonary disease (COPD). Totally 72 patients with acute exacerbation of COPD (AECOPD group) and 65 patients with stable COPD (S-COPD group) were recruited from Tianjin Chest Hospital from June 2016 to August 2017. In the same period 40 elderly healthy subjects were selected as control group (C group). The general data and laboratory examination results of these subjects were recorded. Serum IL-38 was measured by double antibody enzyme-linked immunosorbent assays (ELISA). The inter-group differences of above parameters were analyzed. Pearson correlation or Spearman rank correlation analysis was used to analyze the correlation between IL-38 and each variable, and multivariate stepwise regression analysis was used to determine the influencing factors of serum IL-38 in COPD patients. The serum level of IL-38 was higher in AECOPD group than in S-COPD group[(57.88±13.72) vs (51.75±14.06) ng/L, <0.05], and was higher in either of the two COPD groups than in C group[(46.37±13.18) ng/L](both <0.05). Correlation analysis of single factor showed that serum IL-38 levels were positively correlated with body mass index (=0.190, <0.05), and negatively correlated with C reactive protein (CRP), fibrinogen (FIB), forced expiratory volume in one second as a percentage of estimated value (FEV%pred) and the number of acute exacerbations in the past 1 year (=-0.344, -0.176, -0.195, -0.229, all <0.05). The CRP level and the number of acute exacerbations in the past 1 year were independent factors affecting the serum level of IL-38 (β=-0.204, -0.183, both <0.05) in patients with COPD. IL-38 is compensatory increased in serum of patients with COPD and may be used as one of the serological markers for evaluation of COPD.
探讨慢性阻塞性肺疾病（COPD）患者血清白细胞介素 - 38（IL - 38）水平及其临床意义。2016年6月至2017年8月，从天津市胸科医院招募了72例慢性阻塞性肺疾病急性加重期患者（AECOPD组）和65例稳定期COPD患者（S - COPD组）。同期选取40例老年健康受试者作为对照组（C组）。记录这些受试者的一般资料和实验室检查结果。采用双抗体酶联免疫吸附测定（ELISA）法检测血清IL - 38。分析上述参数的组间差异。采用Pearson相关分析或Spearman等级相关分析分析IL - 38与各变量之间的相关性，并采用多元逐步回归分析确定COPD患者血清IL - 38的影响因素。AECOPD组血清IL - 38水平高于S - COPD组[（57.88±13.72）对（51.75±14.06）ng/L，P<0.05]，且COPD两组中的任何一组均高于C组[（46.37±13.18）ng/L]（均P<0.05）。单因素相关分析显示，血清IL - 38水平与体重指数呈正相关（r = 0.190，P<0.05），与C反应蛋白（CRP）、纤维蛋白原（FIB）、一秒用力呼气容积占预计值百分比（FEV%pred）及过去1年急性加重次数呈负相关（r = - 0.344、- 0.176、- 0.195、- 0.229，均P<0.05）。CRP水平和过去1年急性加重次数是影响COPD患者血清IL - 38水平的独立因素（β = - 0.204、- 0.183，均P<0.05）。COPD患者血清中IL - 38呈代偿性升高，可能作为评估COPD的血清学标志物之一。
