Xu Wang-Dong, Huang An-Fang
Department of Evidence-Based Medicine, School of Public Health, Southwest Medical University, Luzhou, China.
Department of Rheumatology and Immunology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Front Immunol. 2018 Jun 22;9:1462. doi: 10.3389/fimmu.2018.01462. eCollection 2018.
Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to several receptors, regulate the generation, function of inflammatory cytokines through the downstream signaling pathways. IL-38 is expressed in several tissues, such as placenta, heart, and brain. It is involved in a wide variety of diseases, including chronic inflammatory diseases. In this review, we discuss the expression and biological functions of IL-38, especially the role in rheumatic autoimmune diseases. Collection of the information may improve the understanding of IL-38, and may give potential for theoretical basis for clinical trials and drug development in the future.
白细胞介素（IL）-38是白细胞介素-1家族的最新成员。它可以与多种受体结合，通过下游信号通路调节炎性细胞因子的产生和功能。IL-38在多种组织中表达，如胎盘、心脏和大脑。它参与多种疾病，包括慢性炎症性疾病。在本综述中，我们讨论了IL-38的表达和生物学功能，特别是在风湿性自身免疫性疾病中的作用。收集这些信息可能会增进对IL-38的理解，并可能为未来的临床试验和药物开发提供理论基础。
