McCoy Jennifer, Downes Katheryne L, Srinivas Sindhu K, Levine Lisa D
a Maternal and Child Health Research Center , Department of Obstetrics & Gynecology , University of Pennsylvania, Perelman School of Medicine , Philadelphia , PA , USA.
J Matern Fetal Neonatal Med. 2019 Sep;32(17):2874-2878. doi: 10.1080/14767058.2018.1450861. Epub 2018 Mar 21.
To determine the risk of cesarean delivery associated with postdates induction (≥41 weeks) compared to term induction (37-40w6d) among women with an unfavorable cervix, and to examine the risk factors associated with cesarean among women undergoing postdates induction. A planned secondary analysis of a large prospective cohort study on induction ( = 854) was performed. Women with a singleton gestation, intact membranes, and an unfavorable cervix (Bishop score of ≤6 and dilation ≤2 cm) who were undergoing a term (≥37 weeks) induction for any indication were included. Women with a prior cesarean were excluded. The primary outcome was cesarean delivery. Relative risk of cesarean was estimated using a modified Poisson's regression model. There was a significantly increased risk of cesarean for women undergoing postdates induction ( = 154) compared to women 37-40w6d ( = 700), (46.8 versus 26.0%, < .001). This increased risk of cesarean remained after adjustment for race, parity, and pregnancy-related hypertension (aRR 1.70 [1.39-2.09], < .001). Risk factors independently associated with cesarean among women ≥41 weeks included nulliparity (aRR 3.38 95%CI (2.42-4.74)), BMI ≥30 (aRR 1.72 95%CI (1.34-2.21)), and starting cervical dilation <1 cm (aRR 1.37 95%CI (1.11-1.70)). Women ≥41 weeks undergoing an induction with an unfavorable cervix are at a significantly increased risk of cesarean compared to women 37-40w6d, with nulliparity, obesity, and cervical dilation <1 cm being independent risk factors. These data can be used to augment patient counseling and support the ongoing discussion regarding the risk of post dates induction.
为了确定与宫颈条件不佳的女性足月引产(37 - 40周6天)相比,过期引产(≥41周)相关的剖宫产风险,并检查过期引产女性剖宫产的相关危险因素。对一项关于引产的大型前瞻性队列研究(n = 854)进行了计划中的二次分析。纳入单胎妊娠、胎膜完整且宫颈条件不佳(Bishop评分≤6且宫颈扩张≤2 cm)且因任何指征接受足月(≥37周)引产的女性。排除有剖宫产史的女性。主要结局是剖宫产。使用改良的泊松回归模型估计剖宫产的相对风险。与37 - 40周6天的女性(n = 700)相比,过期引产的女性(n = 154)剖宫产风险显著增加(46.8%对26.0%,P <.001)。在调整种族、产次和妊娠相关高血压后,这种增加的剖宫产风险仍然存在(调整后相对风险1.70 [1.39 - 2.09],P <.001)。≥41周女性中与剖宫产独立相关的危险因素包括初产(调整后相对风险3.38,95%置信区间(2.42 - 4.74))、体重指数≥30(调整后相对风险1.72,95%置信区间(1.34 - 2.21))以及起始宫颈扩张<1 cm(调整后相对风险1.37,95%置信区间(1.11 - 1.70))。与37 - 40周6天的女性相比,宫颈条件不佳的≥41周引产女性剖宫产风险显著增加,初产、肥胖和宫颈扩张<1 cm是独立危险因素。这些数据可用于加强患者咨询,并支持正在进行的关于过期引产风险的讨论。