Nicolescu Mihnea Ioan
Carol Davila University of Medicine and Pharmacy, Faculty of Dental Medicine, Histology and Cytology Division, Bucharest, 8 Eroilor Sanitari Blvd., RO-050474, Romania.
Victor Babeș National Institute of Pathology, Radiobiology Laboratory, Bucharest, Romania.
Dent J (Basel). 2016 Apr 25;4(2):10. doi: 10.3390/dj4020010.
This review aims to trace the contour lines of regenerative dentistry, to offer an introductory overview on this emerging field to both dental students and practitioners. The crystallized depiction of the concept is a translational approach, connecting dental academics to scientific research and clinical utility. Therefore, this review begins by presenting the general features of regenerative medicine, and then gradually introduces the specific aspects of major dental subdomains, highlighting the progress achieved during the last years by scientific research and, in some cases, which has already been translated into clinical results. The distinct characteristics of stem cells and their microenvironment, together with their diversity in the oral cavity, are put into the context of research and clinical use. Examples of regenerative studies regarding endodontic and periodontal compartments, as well as hard (alveolar bone) and soft (salivary glands) related tissues, are presented to make the reader further acquainted with the topic. Instead of providing a conclusion, we will emphasize the importance for all dental community members, from young students to experienced dentists, of an early awareness rising regarding biomedical research progress in general and regenerative dentistry in particular.
本综述旨在勾勒再生牙科的轮廓，为牙科学生和从业者提供关于这一新兴领域的入门概述。该概念的明确描述是一种转化方法，将牙科学术界与科学研究及临床应用联系起来。因此，本综述首先介绍再生医学的一般特征，然后逐步引入主要牙科亚领域的具体方面，突出过去几年科学研究取得的进展，在某些情况下，这些进展已转化为临床成果。干细胞及其微环境的独特特征，以及它们在口腔中的多样性，都放在研究和临床应用的背景下进行阐述。文中列举了关于牙髓腔和牙周组织以及硬组织（牙槽骨）和软组织（唾液腺）相关组织的再生研究实例，以使读者进一步熟悉该主题。我们不会给出结论，而是强调对于牙科界所有成员，从年轻学生到经验丰富的牙医，尽早认识到一般生物医学研究进展尤其是再生牙科进展的重要性。
