Orofacial Development and Regeneration, Institute of Oral Biology, Centre of Dental Medicine, University of Zurich, Switzerland; Department of Clinical Sciences and Stomatology, Polytechnic University of Marche, Ancona, Italy.
Orofacial Development and Regeneration, Institute of Oral Biology, Centre of Dental Medicine, University of Zurich, Switzerland.
Am J Med. 2018 Dec;131(12):1425-1430. doi: 10.1016/j.amjmed.2018.05.042. Epub 2018 Jun 30.
Traumatic injuries, genetic diseases, and external harmful agents such as bacteria and acids often compromise tooth integrity. There is an unmet medical need to develop alternative, innovative dental treatments that complement traditional restorative and surgery techniques. Stem cells have transformed the medical field in recent years. The combination of stem cells with bioactive scaffolds and nanostructured materials turns out to be increasingly beneficial in regenerative dental medicine. Stem cell-based regenerative approaches for the formation of dental tissues will significantly improve treatments and will have a major impact in dental practice. To date there is no established and reliable stem cell-based treatment translated into the dental clinics, however, the advances and improved technological knowledge are promising for successful dental therapies in the near future. Here, we review some of the contemporary challenges in dental medicine and describe the benefits and future possibilities of certain novel approaches in the emerging field of regenerative dentistry.
创伤、遗传疾病以及细菌和酸等外部有害因子常常会损害牙齿的完整性。因此，开发替代传统修复和手术技术的创新牙科治疗方法具有重要的医学意义。近年来，干细胞已经改变了医学领域。将干细胞与生物活性支架和纳米结构材料相结合，在再生牙科医学中变得越来越有益。基于干细胞的牙组织形成再生方法将极大地改善治疗效果，并在牙科实践中产生重大影响。尽管目前还没有一种基于干细胞的成熟可靠的治疗方法被应用于牙科临床，但这些进步和技术知识的提高有望在不久的将来为成功的牙科治疗提供保障。在这里，我们回顾了一些当代牙科医学的挑战，并描述了再生牙科领域新兴的一些新方法的优势和未来可能性。
