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在使用紫杉醇和曲妥珠单抗进行新辅助治疗期间发生的急性局部自发性大量牙龈出血。

Acute Local Spontaneous and Profuse Gingival Hemorrhage during Neoadjuvant Treatment with Paclitaxel and Trastuzumab.

作者信息

Sarmast Nima D, Gutierrez Quevedo Maria J, Wang Howard H, Gutierrez Herrera Estatio R

机构信息

Department of Periodontics and Dental Hygiene, The University of Texas School of Dentistry at Houston, Houston, TX 77054, USA.

Private Dental Practice, Houston, TX 77064, USA.

出版信息

Dent J (Basel). 2016 Jun 24;4(3):22. doi: 10.3390/dj4030022.

DOI:10.3390/dj4030022
PMID:29563464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5806938/
Abstract

This case report describes a 33-year-old female currently undergoing breast cancer treatment following the AC-T-T (doxorubicin hydrochloride (Adriamycin) and cyclophosphamide followed by paclitaxel (Taxol) and trastuzumab (Herceptin)) treatment regimen. Her chief complaint at the time of the emergency visit at the dental office was that she had an episode of profuse spontaneous bleeding located at the palatal gingiva in the maxilla between the left central and lateral incisor. To our knowledge, this is a novel finding related to the medications she is utilizing and should be further investigated.

摘要

本病例报告描述了一名33岁女性,她目前正在接受AC-T-T(盐酸多柔比星(阿霉素)和环磷酰胺,随后是紫杉醇(泰素)和曲妥珠单抗(赫赛汀))治疗方案的乳腺癌治疗。她在牙科诊所急诊就诊时的主要诉求是,她的上颌左侧中切牙和侧切牙之间的腭侧牙龈出现了一次大量自发性出血。据我们所知,这是一个与她正在使用的药物相关的新发现,应进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6615/5806938/d3d708616db9/dentistry-04-00022-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6615/5806938/78e44e4c3c58/dentistry-04-00022-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6615/5806938/812bc6957f83/dentistry-04-00022-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6615/5806938/d3d708616db9/dentistry-04-00022-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6615/5806938/78e44e4c3c58/dentistry-04-00022-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6615/5806938/812bc6957f83/dentistry-04-00022-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6615/5806938/d3d708616db9/dentistry-04-00022-g003.jpg

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本文引用的文献

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J Clin Oncol. 2016 Feb 20;34(6):581-7. doi: 10.1200/JCO.2015.61.8413. Epub 2015 Sep 21.
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Periodontal systemic associations: review of the evidence.牙周病与全身健康的关联:证据综述
J Clin Periodontol. 2013 Apr;40 Suppl 14:S8-19. doi: 10.1111/jcpe.12064.
3
Dentistry and internal medicine: from the focal infection theory to the periodontal medicine concept.牙科学与内科学:从病灶感染理论到牙周病医学概念。
Eur J Intern Med. 2010 Dec;21(6):496-502. doi: 10.1016/j.ejim.2010.07.011.
4
Periodontal diseases and health: Consensus Report of the Sixth European Workshop on Periodontology.牙周疾病与健康:第六届欧洲牙周病学研讨会共识报告
J Clin Periodontol. 2008 Sep;35(8 Suppl):333-7. doi: 10.1111/j.1600-051X.2008.01278.x.
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Preoperative therapy in invasive breast cancer: pathologic assessment and systemic therapy issues in operable disease.浸润性乳腺癌的术前治疗:可手术疾病的病理评估及全身治疗问题
J Clin Oncol. 2008 Feb 10;26(5):814-9. doi: 10.1200/JCO.2007.15.3510.
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Trastuzumab--mechanism of action and use in clinical practice.曲妥珠单抗——作用机制及临床应用
N Engl J Med. 2007 Jul 5;357(1):39-51. doi: 10.1056/NEJMra043186.
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Periodontol 2000. 2004;34:9-21. doi: 10.1046/j.0906-6713.2002.003421.x.
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