Klute Lauren, Solverson Matthew, Bingcang Christopher M, Dowdall Jayme R
University of Nebraska Medical Center, Department of Otolaryngology-Head and Neck Surgery, 981225 Nebraska Medical Center, Omaha, Nebraska 68198-1225, USA.
Case Rep Otolaryngol. 2020 Aug 22;2020:8818905. doi: 10.1155/2020/8818905. eCollection 2020.
Drug-induced epithelial hemorrhage of the endolarynx is an unusual etiology of hemoptysis. We present a case of hemoptysis in a young female patient undergoing treatment for metastatic breast cancer with trastuzumab emtansine. Though previously associated with diffuse spontaneous hemorrhage of the gingiva, there have not been reports of laryngeal hemorrhage with trastuzumab emtansine treatment. In this case report, we suggest that trastuzumab emtansine played a contributory role in the development of diffuse epithelial laryngeal hemorrhage and describe the pathophysiology, history, laryngoscopic findings, and management of this condition.
药物性喉内上皮出血是咯血的一种不常见病因。我们报告一例年轻女性转移性乳腺癌患者在接受曲妥珠单抗-恩杂鲁胺治疗时出现咯血的病例。尽管此前曾有曲妥珠单抗-恩杂鲁胺与牙龈弥漫性自发性出血相关的报道，但尚无该药物治疗导致喉部出血的报告。在本病例报告中，我们认为曲妥珠单抗-恩杂鲁胺在弥漫性喉上皮出血的发生中起了一定作用，并描述了该病症的病理生理学、病史、喉镜检查结果及治疗方法。
