Department of Plastic Surgery, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Sci Rep. 2018 Mar 21;8(1):4924. doi: 10.1038/s41598-018-22814-8.
The authors investigated relations between obesity, age, and sex and the availabilities of striatal dopamine transporter (DAT) and extrastriatal serotonin transporter (SERT) by I-FP-CIT single-photon emission computed tomography. The study population consisted of 192 healthy controls with screening I-FP-CIT scans. Specific bindings of I-FP-CIT to DAT and SERT were calculated using regions of interest. Specific binding ratios (SBRs) of DAT and SERT except pons (r = 0.2217, p = 0.0026), were not correlated with body mass index (BMI). SBRs of midbrains correlated negatively with the BMIs of obese subjects (r = -0.3126, p = 0.0496), and positively with the those of non-obese subjects (r = 0.2327, p = 0.0053). SBRs of caudate nucleus (r = -0.3175, p < 0.0001), striatum (r = -0.226, p = 0.0022), and thalamus (r = -0.1978, p = 0.0074) reduced with age, and SERT availability was higher in males. However, DAT availability was similar in males and females. In conclusion, obesity has an effect on midbrain SERT availability. In addition, BMI was correlated with pontine SERT availability but not with striatal DAT availability. SERT availability was higher in males, but DAT availability showed no gender predilection.
作者通过 I-FP-CIT 单光子发射计算机断层扫描研究了肥胖、年龄和性别与纹状体多巴胺转运体 (DAT) 和纹状体外 5-羟色胺转运体 (SERT) 的可利用性之间的关系。研究人群由 192 名有筛选 I-FP-CIT 扫描的健康对照组成。使用感兴趣区计算 I-FP-CIT 对 DAT 和 SERT 的特异性结合。除脑桥外（r=0.2217，p=0.0026），DAT 和 SERT 的特异性结合比（SBR）与体重指数（BMI）无关。中脑 SBR 与肥胖受试者的 BMI 呈负相关（r=-0.3126，p=0.0496），与非肥胖受试者的 BMI 呈正相关（r=0.2327，p=0.0053）。尾状核（r=-0.3175，p<0.0001）、纹状体（r=-0.226，p=0.0022）和丘脑（r=-0.1978，p=0.0074）的 SBR 随年龄降低，SERT 可用性在男性中更高。然而，DAT 可用性在男性和女性中相似。总之，肥胖对中脑 SERT 的可用性有影响。此外，BMI 与脑桥 SERT 可用性相关，但与纹状体 DAT 可用性无关。SERT 可用性在男性中更高，但 DAT 可用性没有性别偏好。
