Shukla Nootan Kumar, Deo S V Suryanarayana, Garg Pankaj Kumar, Manjunath N M L, Bhaskar Suman, Sreenivas V
1Department of Surgical Oncology, Dr BRA Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, 110029 India.
2Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Delhi, 110095 India.
Indian J Surg Oncol. 2018 Mar;9(1):15-23. doi: 10.1007/s13193-017-0658-x. Epub 2017 May 11.
The aim of the present study was to provide insight into various demographic, clinical, and management profile of Indian patients with oral tongue squamous cell cancer (OTSCC). All the OTSCC patients who had undergone surgical treatment during 1995 to 2010 at a tertiary care center in North India were considered for the present study. The details of the patients were retrieved from a prospectively maintained computerized database. A total of 124 patients were included in the present study. Mean age of the patients was 50.4 ± 12.0 years. Lateral border of the tongue was the most common sub-site involved in 110 (88.7%) patients. Neck nodes were clinically palpable in 56.4% patients. Hemiglossectomy and anterior partial glossectomy were common surgical procedure undertaken in 57.2 and 25.8% patients. Negative resection margin was achieved in 97.5% patients. Pathological neck metastasis was seen in 40.3% patients. Occult neck metastasis was present in 25.9% patients among clinical N0 neck. At a mean follow-up of 29.8 months (SD 3.1), 20.1% developed disease relapse and 4.0% patients developed second primaries. Kaplan-Meier analysis estimated a 5-year disease-free survival of 81.5% and a 5 years overall survival of 78.6%. Cox proportional regression analysis predicted tumor size and number of positive nodes to be independent predictive variables for disease recurrence. Quality controlled surgery, coupled with adjuvant treatment when required, provides a safe and effective treatment of OTSCC with a good disease-free survival and loco-regional control.
本研究的目的是深入了解印度口腔舌鳞状细胞癌（OTSCC）患者的各种人口统计学、临床和管理特征。本研究纳入了1995年至2010年期间在印度北部一家三级医疗中心接受手术治疗的所有OTSCC患者。患者的详细信息从一个前瞻性维护的计算机数据库中检索。本研究共纳入124例患者。患者的平均年龄为50.4±12.0岁。舌侧缘是最常见的受累亚部位，110例（88.7%）患者受累。56.4%的患者颈部淋巴结在临床上可触及。57.2%和25.8%的患者分别进行了半舌切除术和前部部分舌切除术。97.5%的患者实现了阴性切缘。40.3%的患者出现病理性颈部转移。在临床N0颈部患者中，25.9%的患者存在隐匿性颈部转移。平均随访29.8个月（标准差3.1），20.1%的患者出现疾病复发，4.0%的患者出现第二原发肿瘤。Kaplan-Meier分析估计5年无病生存率为81.5%，5年总生存率为78.6%。Cox比例回归分析预测肿瘤大小和阳性淋巴结数量是疾病复发的独立预测变量。质量可控的手术，必要时辅以辅助治疗，可为OTSCC提供安全有效的治疗，具有良好的无病生存率和局部区域控制效果。
