Department of Mechanical and Aerospace Engineering, Monash University, Melbourne, VIC.
The Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia.
Int J Nanomedicine. 2018 Mar 8;13:1353-1359. doi: 10.2147/IJN.S153805. eCollection 2018.
This article presents an acoustically enhanced microfluidic mixer to generate highly uniform and ultra-fine nanoparticles, offering significant advantages over conventional liquid antisolvent techniques.
The method employed a 3D microfluidic geometry whereby two different phases - solvent and antisolvent - were introduced at either side of a 1 μm thick resonating membrane, which contained a through-hole. The vibration of the membrane rapidly and efficiently mixed the two phases, at the location of the hole, leading to the formation of nanoparticles.
The versatility of the device was demonstrated by synthesizing budesonide (a common asthma drug) with a mean diameter of 135.7 nm and a polydispersity index of 0.044.
The method offers a 40-fold reduction in the size of synthesized particles combined with a substantial improvement in uniformity, achieved without the need of stabilizers.
本文提出了一种声学增强微流混合器，用于生成高度均匀和超细微纳米颗粒，与传统的液体抗溶剂技术相比具有显著优势。
该方法采用了 3D 微流几何形状，其中溶剂和抗溶剂两种不同的相在 1μm 厚的共振膜的两侧引入，该膜包含一个通孔。膜的振动迅速有效地将两种相在孔的位置混合，导致纳米颗粒的形成。
该设备的多功能性通过用平均直径为 135.7nm 和多分散指数为 0.044 的布地奈德（一种常见的哮喘药物）进行合成来证明。
该方法将合成颗粒的尺寸缩小了 40 倍，同时均匀度得到了实质性的提高，而且不需要稳定剂。
