Ladhari Taoufik, Szafnicki Konrad
ESIER, ENIM, Ibn El Jazzar Street, Skanes, 5000 Monastir, Tunisia.
CentraleSupelec, 2 rue Edouard Belin, 57070 Metz, France.
3 Biotech. 2018 Apr;8(4):190. doi: 10.1007/s13205-018-1211-5. Epub 2018 Mar 20.
Usual therapies against malignant tumors, such as surgery, chemotherapy, radiation, is severe and when repeated their efficiency may decrease because tumorous cells may become resistant. Contrarily, hyperthermia has been known for some time as an effective auxiliary treatment, which can be applied repeatedly. In some cases of abdominal carcinomatosis, particularly those of digestive origin, HIPEC is considered as an promising therapeutic option. Chemotherapy and hyperthermia are combined via the perfusion of the abdominal cavity with hot fluids containing chemotherapeutic agents, thus, augmenting the influence of appropriate chemotherapeutic agents with heat. The paper deals with in vivo temperature measurements during the treatment and the identification and development of a heat transfer model of the treatment and consequently its optimization. First, the focus is on in vivo acquisition and monitoring of temperatures. Temperature probe characteristics are identified. Next, a dynamic model for the heat transfer in the patient's body during the HIPEC is outlined. Then model is validated using experimental data collected by the medical partners (St-Etienne Bellevue and Lyon-Sud, France) during in vivo HIPEC. Finally, the concluding comments are reported, including the current perspectives. Since the effectiveness of HIPEC is based on the achievement of a uniform hyperthermic intracavity temperature, properly modelling and developing supervising/monitoring methods for heat transfer for this procedure is the motivation for this research. The paper presents some preliminary groundwork for an eventual simulator and decision aid related to HIPEC.
针对恶性肿瘤的常规治疗方法，如手术、化疗、放疗，都很严苛，且反复使用时效果可能会降低，因为肿瘤细胞可能会产生耐药性。相反，热疗作为一种有效的辅助治疗方法已为人所知一段时间了，它可以反复应用。在某些腹部癌病的病例中，尤其是那些起源于消化系统的病例，腹腔内热灌注化疗（HIPEC）被认为是一种有前景的治疗选择。化疗和热疗通过向腹腔灌注含有化疗药物的热流体相结合，从而增强合适化疗药物与热的协同作用。本文探讨了治疗过程中的体内温度测量以及治疗热传递模型的识别、开发并对其进行优化。首先，重点在于体内温度的采集与监测。确定了温度探头的特性。接下来，概述了腹腔内热灌注化疗过程中患者体内热传递的动态模型。然后使用医疗合作伙伴（法国圣艾蒂安贝莱维医院和里昂南医院）在体内腹腔内热灌注化疗期间收集的实验数据对该模型进行了验证。最后，给出了结论性评论，包括当前的研究前景。由于腹腔内热灌注化疗的有效性基于实现均匀的腔内高温，因此为该过程正确建模并开发热传递的监测方法是本研究的动机。本文为最终的腹腔内热灌注化疗模拟器和决策辅助工具提供了一些初步基础工作。
