Kazeminezhad Behrang, Baradaran Behdad, Hafezi Ahmadi Mohammad Reza
Department of Pathology, Clinical Research Development Center, Shahid Beheshti University of Medical Sciences, Shahid Modarres Hospital, Tehran, Iran.
Department of Pathology, Ilam University of Medical Sciences, Ilam, Iran.
J Family Med Prim Care. 2017 Oct-Dec;6(4):770-774. doi: 10.4103/jfmpc.jfmpc_177_17.
Recently, hepatoma-derived growth factor (HDGF) has been considered as a significantly important factor in determining the prognosis and estimating the probability of tumor cell invasions, recurrence, and lymph node metastasis in different cancers, including breast malignancies.
Immunohistochemistry (IHC) study for HDGF was performed on paraffin-embedded blocks of patients with breast carcinoma in Modarres hospital, Tehran, Iran, since 1387-1390 (74 cases); three separate pathologists read the slides after complete IHC staining. Thereafter, necessary information was recorded from patient files, and eventually, findings were analyzed by SPSS program.
Expression of nuclear HDGF has significant statistical correlation with tumor grade according to Nottingham grading scheme; this correlation is also seen with nuclear pleomorphism of tumor cells and mitotic count. No correlation between age and tumor size with expression of HDGF is found. Lymph node metastasis is in inverse ratio to nuclear HDGF staining.
Nuclear expression of HDGF in tumor cells is increased concordantly to tumor grade, which implies us to the role of this marker in determining the prognosis and choosing the most suitable treatment plan.
最近，肝癌衍生生长因子（HDGF）被认为是决定不同癌症（包括乳腺恶性肿瘤）预后以及评估肿瘤细胞侵袭、复发和淋巴结转移可能性的一个极为重要的因素。
自1387 - 1390年起，对伊朗德黑兰莫达雷斯医院乳腺癌患者的石蜡包埋组织块进行HDGF免疫组织化学（IHC）研究（74例）；在完成IHC染色后，由三位独立的病理学家阅片。此后，从患者病历中记录必要信息，最终通过SPSS程序对结果进行分析。
根据诺丁汉分级方案，核HDGF的表达与肿瘤分级具有显著的统计学相关性；在肿瘤细胞核异形性和有丝分裂计数方面也存在这种相关性。未发现年龄和肿瘤大小与HDGF表达之间存在相关性。淋巴结转移与核HDGF染色呈反比。
肿瘤细胞核HDGF表达随肿瘤分级同步增加，这提示该标志物在决定预后和选择最合适治疗方案方面的作用。
