Anil Sethulakshmi Sreevalsam, Ratnakaran Badr, Suresh Nisha
Department of Psychiatry, Government Medical College, Thiruvananthapuram, Kerala, India.
Department of Psychiatry, Dr. Kunhalu's Nursing Home, Ernakulam, Kerala, India.
J Family Med Prim Care. 2017 Oct-Dec;6(4):878-880. doi: 10.4103/jfmpc.jfmpc_205_17.
Hyponatremia has been reported with the use of psychotropic drugs. Olanzapine does not find much mention as a cause of hyponatremia in literature; however, it has been found to be the second most frequently reported atypical antipsychotic to cause it. We report a case of hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion which occurred at a rapid onset following the administration of low-dose olanzapine during inpatient treatment of a patient with bipolar disorder. We would like to highlight our case for the need to be vigil about such fatal side complications apart from metabolic side effects of atypical antipsychotics.
已有报道使用精神药物会导致低钠血症。在文献中，奥氮平作为低钠血症的病因提及不多；然而，它已被发现是导致低钠血症的第二常见的非典型抗精神病药物。我们报告一例因抗利尿激素分泌不当综合征导致的低钠血症病例，该病例发生在一名双相情感障碍患者住院治疗期间服用低剂量奥氮平后迅速出现。我们想强调我们的病例，除了非典型抗精神病药物的代谢副作用外，还需要警惕此类致命的副作用。
