Khatun Amena, Rahman Md Saidur, Pang Myung-Geol
Department of Animal Science and Technology, Chung-Ang University, Anseong, Korea.
Obstet Gynecol Sci. 2018 Mar;61(2):179-191. doi: 10.5468/ogs.2018.61.2.179. Epub 2018 Mar 5.
The evaluation of infertility in males consists of physical examination and semen analyses. Standardized semen analyses depend on the descriptive analysis of sperm motility, morphology, and concentration, with a threshold level that must be surpassed to be considered a fertile spermatozoon. Nonetheless, these conventional parameters are not satisfactory for clinicians since 25% of infertility cases worldwide remain unexplained. Therefore, newer tests methods have been established to investigate sperm physiology and functions by monitoring characteristics such as motility, capacitation, the acrosome reaction, reactive oxygen species, sperm DNA damage, chromatin structure, zona pellucida binding, and sperm-oocyte fusion. After the introduction of intracytoplasmic sperm injection technique, sperm maturity, morphology, and aneuploidy conditions have gotten more attention for investigating unexplained male infertility. In the present article, recent advancements in research regarding the utilization of male fertility prediction tests and their role and accuracy are reviewed.
男性不育症的评估包括体格检查和精液分析。标准化的精液分析依赖于对精子活力、形态和浓度的描述性分析，要有超过一定阈值水平才能被视为有生育能力的精子。然而，这些传统参数对临床医生来说并不令人满意，因为全球25%的不育病例仍无法解释原因。因此，已经建立了更新的测试方法，通过监测诸如活力、获能、顶体反应、活性氧、精子DNA损伤、染色质结构、透明带结合以及精子-卵母细胞融合等特征来研究精子生理和功能。在引入胞浆内单精子注射技术后，精子成熟度、形态和非整倍体情况在调查不明原因的男性不育症时受到了更多关注。在本文中，将对男性生育力预测测试的应用、其作用和准确性的最新研究进展进行综述。
