Paola Algeri, Maria Rota Sonia, Laura Carlini, Elena Nicoli, Orlando Caruso, Teresio Motta
Department of Obstetrics and Gynecology, University of Milano-Bicocca, MBBM Foundation, San Gerardo Hospital, Monza, Italy.
Department of Obstetrics and Gynecology, Bolognini Hospital, Seriate, Italy.
Obstet Gynecol Sci. 2018 Mar;61(2):282-285. doi: 10.5468/ogs.2018.61.2.282. Epub 2018 Feb 13.
Primary ovarian melanoma arising on a mature ovarian cystic teratoma is extremely rare. As best of our knowledge, to date, 49 cases have been reported in literature. Few information was reported about best management and therapy. We present a case occurred in a 69-year-old woman, without symptoms, who come to our unit for stress incontinence. A pelvic mass was detected and, after imaging evaluation, surgery was performed. The diagnosis was ovarian melanoma arose on a mature teratoma. No other adjuvant treatment was proposed after surgery. She died 9 months after the first diagnosis. Primary ovarian melanoma is a definite entity associated with a variable natural history and poor prognosis. Differential diagnosis is a challenge for the pathologist, because it must be differentiated by metastatic melanoma. The corner stone treatment of this disease is surgery; however, chemotherapy, immunotherapy, and target therapy seem to have a role.
原发性卵巢黑色素瘤起源于成熟的卵巢囊性畸胎瘤极为罕见。据我们所知，迄今为止，文献中已报道49例。关于最佳管理和治疗的报道信息很少。我们报告一例发生在一名69岁无症状女性身上的病例，她因压力性尿失禁前来我们科室就诊。检测到盆腔肿块，经影像学评估后进行了手术。诊断为起源于成熟畸胎瘤的卵巢黑色素瘤。术后未建议进行其他辅助治疗。首次诊断9个月后她去世了。原发性卵巢黑色素瘤是一种明确的疾病，其自然史多变且预后不良。鉴别诊断对病理学家来说是一项挑战，因为它必须与转移性黑色素瘤相鉴别。这种疾病的基石治疗方法是手术；然而，化疗、免疫疗法和靶向疗法似乎也有作用。
