Luo Cheng-Xin, Wen Zhong-Hui, Zhen Yu, Wang Zhu-Jun, Mu Jing-Xi, Zhu Min, Ouyang Qin, Zhang Hu
Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
World J Clin Cases. 2018 Mar 16;6(3):35-43. doi: 10.12998/wjcc.v6.i3.35.
To investigate the current state of research output from Chinese studies into severe ulcerative colitis (SUC) using a bibliometric analysis of publications.
The contents of the Chinese periodical databases WANFANG, VIP, and China National Knowledge Infrastructure were searched for all papers regarding UC or SUC published in last the 15 years (from 2001 to 2015). The number of publications in each year was recorded to assess the temporal trends of research output. All SUC related publications were downloaded and the complexity of this research was evaluated with methods described previously. The number of patients with SUC reported each year was recorded and their clinical characteristics were analyzed using information available in the relevant papers.
There were 13499 publications regarding UC published in Chinese medical journals between 2001 and 2015, of which 201 focused on SUC. The number of publications increased rapidly with more than half of all papers being published in the most recent 5-year period. There was a significant increase in analytical studies and clinical trials over the study period ( < 0.01), with research into the management of SUC, included pharmacotherapy, nutrition support as well as surgery, predominating. Almost half (46.2%) of the observational analytical studies and clinical trials focused on Traditional Chinese Medicine, with little research on the efficacy of cyclosporin and infliximab in disease management. About 6222 patients with SUC were reported in the 201 SUC relevant papers, with a ratio of male/female of 1.38. The number of patients reported in each 5-year period significantly increased. The colectomy rate and short-term mortality rate were 7.7% and 0.8% respectively. The most commonly employed operation was total proctocolectomy with ileal pouch-anal anastomosis.
The output and complexity of research related to SUC in China increased significantly over the previous 15 years, however few of these studies focused on salvage therapy.
通过对出版物的文献计量分析，调查中国重症溃疡性结肠炎（SUC）研究的当前研究产出状况。
在中国期刊数据库万方、维普和中国知网中搜索过去15年（2001年至2015年）发表的所有关于溃疡性结肠炎（UC）或重症溃疡性结肠炎（SUC）的论文。记录每年的出版物数量，以评估研究产出的时间趋势。下载所有与SUC相关的出版物，并使用先前描述的方法评估该研究的复杂性。记录每年报告的SUC患者数量，并使用相关论文中的可用信息分析其临床特征。
2001年至2015年期间，中国医学期刊发表了13499篇关于UC的论文，其中201篇聚焦于SUC。出版物数量迅速增加，超过一半的论文发表在最近5年期间。在研究期间，分析性研究和临床试验显著增加（<0.01），对SUC管理的研究占主导地位，包括药物治疗、营养支持以及手术。几乎一半（46.2%）的观察性分析研究和临床试验聚焦于中医药，而关于环孢素和英夫利昔单抗在疾病管理中的疗效研究较少。在201篇与SUC相关的论文中报告了约6222例SUC患者，男女比例为1.38。每5年报告的患者数量显著增加。结肠切除术率和短期死亡率分别为7.7%和0.8%。最常用的手术是全直肠结肠切除术加回肠储袋肛管吻合术。
在过去15年中，中国与SUC相关的研究产出和复杂性显著增加，然而这些研究中很少有聚焦于挽救治疗的。
