Department of Chemistry, Kansas State University, Manhattan, KS 66506, USA.
Chem Commun (Camb). 2018 May 3;54(37):4657-4660. doi: 10.1039/C8CC01144C.
The solid-form landscape of urea was explored using full interaction maps (FIMs) and data from the CSD to develop optimum protocols for synthesizing co-crystals of urea. As a result, 49 of the 60 attempted reactions produced new co-crystals, and the crystal structures of four of these are presented. Moreover, the goal of reducing the solubility and lowering the hygroscopicity of the parent compound was achieved, which in turn offers new opportunities for application as a slow-release fertilizer with limited hygroscopicity, thereby reducing many current problems of transport, handling, and storage of urea.
利用全相互作用图（FIM）和 CSD 中的数据探索了尿素的固体形态景观，以开发合成尿素共晶的最佳方案。结果，60 次尝试反应中有 49 次产生了新的共晶，其中四个的晶体结构被呈现出来。此外，达到了降低母体化合物的溶解度和吸湿性的目标，这反过来又为应用作为一种具有低吸湿性的缓释肥料提供了新的机会，从而减少了当前尿素在运输、处理和储存方面的许多问题。
