Department of Chemistry, University at Buffalo 730 Natural Sciences Complex, Buffalo, NY 14260-3000, USA.
Department of Chemistry, University at Buffalo 838 Natural Sciences Complex, Buffalo, NY 14260-3000, USA.
Molecules. 2022 Oct 13;27(20):6853. doi: 10.3390/molecules27206853.
The use of crystal engineering to convert liquids into crystalline solids remains a powerful method for inhibiting undesired degradation pathways. When nicotine, a liquid sensitive to both light and air, is combined with the GRAS-listed compound, gentisic acid, the resulting crystalline solid, exhibits enhanced photo and thermal stability. Despite a modest ΔT of 42.7 °C, the melting point of 155.9 °C for the nicotinium gentisate salt is the highest reported for nicotine-containing crystalline solids. An analysis of the crystal packing and thermodynamic properties provides context for the observed properties.
利用晶体工程将液体转化为晶体固体仍然是抑制非期望降解途径的有力方法。当对光和空气均敏感的液体尼古丁与 GRAS 认证化合物龙胆酸结合时，生成的结晶固体表现出增强的光和热稳定性。尽管差热分析（ΔT）值仅为 42.7°C，但尼古丁龙胆酸盐的熔点 155.9°C 是报道的含尼古丁结晶固体中最高的。对晶体堆积和热力学性质的分析为观察到的性质提供了背景。
