Guo Xu-Cheng, Hu Wei-Wen, Tan Say Hwa, Tsao Chia-Wen
Department of Mechanical Engineering, National Central University, Taoyuan, Taiwan.
Centre for Biomedical Cell Engineering, National Central University, Taoyuan, Taiwan.
Biomed Microdevices. 2018 Mar 21;20(2):30. doi: 10.1007/s10544-018-0273-9.
This paper reports a simple method used to fabricate a stretchable conductive polypyrrole (PPy) rough pore-shape polydimethylsiloxane (p-PDMS) device. An abrasive paper is first used to imprint rough micro-structures on the SU-8 micromold. The p-PDMS microchannel is then fabricated using a standard soft-lithography process. An oxygen plasma treatment is then applied to form an irreversible sealing between the microchannel and a blank cover PDMS. The conductive layer is formed by injecting the PPy mixture into the microchannel which polymerizes in the rough pore-shape micro-structures; The PPy/p-PDMS hybrid device shows good electrical property and stretchability. The electrical properties of different geometrical designs of the PPy/p-PDMS microchannel under stretching were investigated, including straight, curved, and serpentine. Mouse embryonic fibroblasts (NIH/3 T3) were also cultured inside the PPy/p-PDMS device to demonstrate good biocompatibility and feasibility using the conductive and stretchable microchannel in cell culture microfluidics applications. Finally, cyclic stretching and bending tests were performed to evaluate the reliability of PPy/p-PDMS microchannel.
本文报道了一种用于制造可拉伸导电聚吡咯（PPy）粗孔状聚二甲基硅氧烷（p-PDMS）器件的简单方法。首先使用砂纸在SU-8微模具上压印粗糙的微结构。然后采用标准的软光刻工艺制造p-PDMS微通道。接着进行氧等离子体处理，以在微通道和空白盖PDMS之间形成不可逆密封。通过将PPy混合物注入在粗糙孔状微结构中聚合的微通道来形成导电层；PPy/p-PDMS混合器件表现出良好的电学性能和可拉伸性。研究了拉伸状态下PPy/p-PDMS微通道不同几何设计的电学性能，包括直线型、曲线型和蛇形。还在PPy/p-PDMS器件内培养了小鼠胚胎成纤维细胞（NIH/3 T3），以证明在细胞培养微流体应用中使用导电且可拉伸的微通道具有良好的生物相容性和可行性。最后，进行循环拉伸和弯曲测试以评估PPy/p-PDMS微通道的可靠性。
