测量小鼠的视网膜功能。

Measuring Retinal Function in the Mouse.

作者信息

Kremers Jan, Tanimoto Naoyuki

机构信息

Department of Ophthalmology, University Hospital Erlangen, Erlangen, Germany.

Department of Ophthalmology, University Hospital Schleswig-Holstein, Kiel, Germany.

出版信息

Methods Mol Biol. 2018;1753:27-40. doi: 10.1007/978-1-4939-7720-8_2.

DOI:10.1007/978-1-4939-7720-8_2

PMID:29564779

Abstract

Electroretinography is a crucial assay for studying the function and the functional integrity of the retina. The mouse is an important animal model for studying the retinal neurons and circuitries. In addition, it is often used as animal model for human retinal disorders. Therefore, a good understanding of the procedures in animal handling, of the methods for data analysis and of the requirements for stimulators and for the data acquisition equipment is of importance. Here, the currently most common methods and materials for in vivo electroretinography in the mouse are discussed.

摘要

视网膜电图是研究视网膜功能及其功能完整性的关键检测方法。小鼠是研究视网膜神经元和神经回路的重要动物模型。此外，它还经常被用作人类视网膜疾病的动物模型。因此，充分了解动物处理程序、数据分析方法以及对刺激器和数据采集设备的要求非常重要。在此，将讨论目前小鼠体内视网膜电图最常用的方法和材料。