Tanimoto Naoyuki, Sothilingam Vithiyanjali, Seeliger Mathias W
Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany.
Methods Mol Biol. 2013;935:69-78. doi: 10.1007/978-1-62703-080-9_4.
In many situations it is important to be able to assess the degree of retinal function, e.g., for the characterization of mouse models with unknown retinal involvement, when studying degenerative processes, for the analysis of visual signal processing, and during the follow-up of therapeutic interventions. Full-field electroretinography (ERG), yielding a sum response of event-related transient electrical activity of the entire retina to light stimulation, is widely applied in human as well as experimental functional diagnostics. ERG examinations normally include initial dark-adapted (scotopic) measurements that enable rod-driven activity to be studied, followed by light-adapted (photopic) recordings to obtain information about cone system contributions. The results allow the correlation of acute or long-term disease-related changes or their alleviation by therapy with morphological data, in order to obtain a comprehensive understanding of the underlying processes and mechanisms.
在许多情况下，能够评估视网膜功能的程度非常重要，例如，在表征视网膜受累情况不明的小鼠模型时、研究退行性病变过程时、分析视觉信号处理时以及治疗干预的随访期间。全视野视网膜电图（ERG）可产生整个视网膜对光刺激的事件相关瞬态电活动的总和反应，广泛应用于人体及实验性功能诊断。ERG检查通常包括初始暗适应（暗视）测量，以研究视杆细胞驱动的活动，随后进行明适应（明视）记录，以获取有关视锥系统贡献的信息。这些结果有助于将急性或长期疾病相关变化或治疗对其的缓解与形态学数据相关联，从而全面了解潜在的过程和机制。
