Aydogan A, Ozmen O, Haligur M, Sipahi C, Ileri D, Haligur A
a University of Cukurova , Faculty of Ceyhan Veterinary Medicine, Department of Pathology , Adana.
b University of Mehmet Akif Ersoy , Faculty of Veterinary Medicine, Department of Pathology , Burdur.
Biotech Histochem. 2018;93(4):286-292. doi: 10.1080/10520295.2018.1434680. Epub 2018 Mar 22.
We investigated the expression of bcl-2, estrogen receptor alpha (ER-alpha), caspase-3, -8, -9, proliferating cell nuclear antigen (PCNA) and Ki-67 in canine mammary carcinomas. We used 65 paraffin embedded and re-diagnosed archival canine mammary tumor samples to which we applied the routine streptavidin-biotin-peroxidase technique. Seventeen cases were re-diagnosed as tubulopapillary carcinoma, 31 were re-diagnosed as complex carcinoma and 17 were re-diagnosed as carcinosarcoma. Differences of expression of bcl-2 and PCNA were statistically significant according to tumor type. Differences in expression of ER-alpha, caspase-3, -8, -9 and Ki-67 were not statistically significant. Differences of expression of bcl-2 and PCNA were statistically significant compared to ER-alpha, caspase-3, -8, -9 and Ki-67 in carcinosarcomas. We report the prognostic significance of bcl-2 and PCNA expression in canine mammary carcinosarcomas.
我们研究了bcl-2、雌激素受体α（ER-α）、半胱天冬酶-3、-8、-9、增殖细胞核抗原（PCNA）和Ki-67在犬乳腺癌中的表达情况。我们使用了65份石蜡包埋并重新诊断的存档犬乳腺肿瘤样本，对其应用常规链霉亲和素-生物素-过氧化物酶技术。17例被重新诊断为管状乳头状癌，31例被重新诊断为复合癌，17例被重新诊断为癌肉瘤。根据肿瘤类型，bcl-2和PCNA的表达差异具有统计学意义。ER-α、半胱天冬酶-3、-8、-9和Ki-67的表达差异无统计学意义。在癌肉瘤中，与ER-α、半胱天冬酶-3、-8、-9和Ki-67相比，bcl-2和PCNA的表达差异具有统计学意义。我们报告了bcl-2和PCNA表达在犬乳腺肉瘤中的预后意义。
