Groch Kátia R, Díaz-Delgado Josué, Sacristán Carlos, Oliveira Denyiélim E, Souza Gabriela, Sánchez-Sarmiento Angélica M, Costa-Silva Samira, Marigo Juliana, Castilho Pedro V, Cremer Marta J, Rodrigues Hoffmann Aline, Esperón Fernando, Catão-Dias José L
Laboratory of Wildlife Comparative Pathology, Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP 05508-270, Brazil.
Dis Aquat Organ. 2018 Mar 22;128(1):73-79. doi: 10.3354/dao03207.
We report the gross and microscopic findings and molecular identification of 2 cases of hyphate fungal infection in cetaceans from Brazil. The first case involved an adult male Atlantic spotted dolphin Stenella frontalis with localized pulmonary disease characterized by pyogranulomatous and necrotizing bronchopneumonia with intralesional hyphae. The second case involved an adult male Bryde's whale Balaenoptera edeni with orchitis, periorchitis, mesenteric lymphadenitis and pyogranulomatous bronchopneumonia with intralesional hyphae. PCR analysis from the dolphin's lung yielded Aspergillus fumigatus, and the fungus from the whale's mesenteric lymph node showed the greatest identity to Nanniziopsis obscura and Stagonosporopsis cucurbitacearum These cases represent the first reports of pulmonary aspergillosis by A. fumigatus in an Atlantic spotted dolphin and systemic mycosis by a possibly novel Onygenales in marine mammals.
我们报告了来自巴西的2例鲸类动物丝状真菌病感染的大体和微观检查结果以及分子鉴定。第一例涉及一头成年雄性大西洋斑点海豚（Stenella frontalis），患有局部肺部疾病，其特征为脓性肉芽肿性和坏死性支气管肺炎，并伴有病灶内菌丝。第二例涉及一头成年雄性布氏鲸（Balaenoptera edeni），患有睾丸炎、睾丸周炎、肠系膜淋巴结炎以及脓性肉芽肿性支气管肺炎，并伴有病灶内菌丝。对海豚肺部进行的PCR分析检出烟曲霉（Aspergillus fumigatus），而从鲸鱼肠系膜淋巴结分离出的真菌与暗黑南尼兹菌（Nanniziopsis obscura）和瓜类叶点霉（Stagonosporopsis cucurbitacearum）最为相似。这些病例代表了大西洋斑点海豚中由烟曲霉引起的肺曲霉病以及海洋哺乳动物中可能由一种新型子囊菌引起的系统性真菌病的首次报道。
