Furlan Alessandro, Almusa Omar, Yu Robinson K, Sagreiya Hersh, Borhani Amir A, Bae Kyongtae T, Marsh J Wallis
1 Department of Radiology, University of Pittsburgh Medical Center , Pittsburgh, PA , United States.
2 Department of Radiology, Brigham and Women's Hospital , Boston, MA , USA.
Br J Radiol. 2018 Jun;91(1086):20170962. doi: 10.1259/bjr.20170962. Epub 2018 Apr 4.
To evaluate the association between the liver imaging reporting and data system (LI-RADS) categories and features and the fractional allelic imbalance (FAI) rate index of hepatocellular carcinoma (HCC).
The institutional review board approved this retrospective study. Medical records collected between January 2008 and December 2013 were reviewed to find patients with histologically confirmed HCC, FAI analysis, and CT or MR imaging of the liver. The final population included 71 patients (54 males, 17 females). Three radiologists reviewed the images using the LI-RADS v. 2014. The association between FAI and LI-RADS categories and features was tested using the Spearman's rank correlation coefficient (rho) and the Wilcoxon rank-sum test [low FAI (<40%) vs high FAI (≥40%)]. A p value < 0.007 was used as the threshold for statistical significance after application of the Bonferroni correction for multiple comparisons.
HCCs were classified as LR-3 (n = 4), LR-4 (n = 22), and LR-5 (n = 45). There was a positive correlation (rho = 0.264) between FAI rate index and LI-RADS category, although not statistically significant after Bonferroni correction (p = 0.024). 14 of the 20 (70%) HCCs with high FAI (≥40%) were categorized as LR-5, 6/20 (30%) as LR-4 and none as LR-3 (p = 0.377). Among the evaluated LI-RADS imaging features, only lesion size showed a statistically significant different distribution in tumors with high FAI compared to those with low FAI. HCCs with FAI ≥40% were larger (56 ± 42 mm) compared to those with FAI <40% (36 ± 30 mm; p = 0.005).
There was a positive correlation, although not statistically significant, between the LI-RADS diagnostic categories and the FAI rate of HCC. Tumors with high FAI were larger compared to those with low FAI. Advances in knowledge: HCCs with high (≥40%) FAI are larger compared to those with low (<40%) FAI.
评估肝脏影像报告和数据系统（LI-RADS）分类及特征与肝细胞癌（HCC）的等位基因不平衡率指数（FAI）之间的关联。
机构审查委员会批准了这项回顾性研究。回顾2008年1月至2013年12月期间收集的病历，以找出经组织学证实患有HCC、进行了FAI分析以及肝脏CT或MR成像的患者。最终纳入71例患者（男性54例，女性17例）。三名放射科医生使用LI-RADS v. 2014对图像进行评估。使用Spearman等级相关系数（rho）和Wilcoxon秩和检验[低FAI（<40%）与高FAI（≥40%）]来检验FAI与LI-RADS分类及特征之间的关联。在应用Bonferroni校正进行多重比较后，将p值<0.007用作具有统计学意义的阈值。
HCC被分类为LR-3（n = 4）、LR-4（n = 22）和LR-5（n = 45）。FAI率指数与LI-RADS分类之间存在正相关（rho = 0.264），尽管在Bonferroni校正后无统计学意义（p = 0.024）。20例高FAI（≥40%）的HCC中有14例（70%）被分类为LR-5，6/20（30%）为LR-4，无LR-3（p = 0.377）。在评估的LI-RADS影像特征中，与低FAI的肿瘤相比，仅病变大小在高FAI的肿瘤中显示出统计学上显著不同的分布。FAI≥40%的HCC比FAI<40%的HCC更大（56±42mm对
