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本文引用的文献

1
Limited Impact of Adolescent Meningococcal ACWY Vaccination on Neisseria meningitidis Serogroup W Carriage in University Students.青少年脑膜炎球菌 ACWY 疫苗接种对大学生中脑膜炎奈瑟菌血清群 W 带菌的影响有限。
J Infect Dis. 2018 Jan 30;217(4):608-616. doi: 10.1093/infdis/jix596.
2
Meningococcal Carriage Following a Vaccination Campaign With MenB-4C and MenB-FHbp in Response to a University Serogroup B Meningococcal Disease Outbreak-Oregon, 2015-2016.2015 - 2016年俄勒冈州针对一起大学B群脑膜炎球菌病暴发开展四价B群脑膜炎球菌结合疫苗（MenB - 4C）和B群脑膜炎球菌因子H结合蛋白疫苗（MenB - FHbp）接种运动后的脑膜炎球菌携带情况
J Infect Dis. 2017 Nov 27;216(9):1130-1140. doi: 10.1093/infdis/jix446.
3
Meningococcal carriage in Dutch adolescents and young adults; a cross-sectional and longitudinal cohort study.荷兰青少年和青年人群中脑膜炎奈瑟菌的带菌情况：一项横断面和纵向队列研究。
Clin Microbiol Infect. 2017 Aug;23(8):573.e1-573.e7. doi: 10.1016/j.cmi.2017.02.008. Epub 2017 Feb 10.
4
Meningococcal Carriage Evaluation in Response to a Serogroup B Meningococcal Disease Outbreak and Mass Vaccination Campaign at a College-Rhode Island, 2015-2016.2015 - 2016年罗德岛一所大学针对B群脑膜炎球菌病暴发及大规模疫苗接种运动开展的脑膜炎球菌携带情况评估
Clin Infect Dis. 2017 Apr 15;64(8):1115-1122. doi: 10.1093/cid/cix091.
5
History of Meningococcal Outbreaks in the United States: Implications for Vaccination and Disease Prevention.美国脑膜炎球菌爆发史：对疫苗接种和疾病预防的启示
Pharmacotherapy. 2016 Aug;36(8):880-92. doi: 10.1002/phar.1790.
6
Meningococcal Vaccinations.脑膜炎球菌疫苗接种。
Infect Dis Ther. 2016 Jun;5(2):89-112. doi: 10.1007/s40121-016-0107-0. Epub 2016 Apr 16.
7
Presentation with gastrointestinal symptoms and high case fatality associated with group W meningococcal disease (MenW) in teenagers, England, July 2015 to January 2016.与青少年群组 W 脑膜炎奈瑟菌病（MenW）相关的胃肠道症状和高病死率病例报告，英格兰，2015 年 7 月至 2016 年 1 月。
Euro Surveill. 2016;21(12). doi: 10.2807/1560-7917.ES.2016.21.12.30175.
8
Genomic epidemiology of age-associated meningococcal lineages in national surveillance: an observational cohort study.国家监测中与年龄相关的脑膜炎球菌谱系的基因组流行病学：一项观察性队列研究。
Lancet Infect Dis. 2015 Dec;15(12):1420-8. doi: 10.1016/S1473-3099(15)00267-4. Epub 2015 Oct 27.
9
Comparison of Phenotypic and Genotypic Approaches to Capsule Typing of Neisseria meningitidis by Use of Invasive and Carriage Isolate Collections.利用侵袭性和携带分离株集合对脑膜炎奈瑟菌进行荚膜分型的表型和基因型方法比较
J Clin Microbiol. 2016 Jan;54(1):25-34. doi: 10.1128/JCM.01447-15. Epub 2015 Aug 26.
10
Disease Burden of Invasive Meningococcal Disease in the Netherlands Between June 1999 and June 2011: A Subjective Role for Serogroup and Clonal Complex.1999 年 6 月至 2011 年 6 月期间荷兰侵袭性脑膜炎奈瑟菌病的疾病负担：血清群和克隆复合物的主观作用。
Clin Infect Dis. 2015 Oct 15;61(8):1281-92. doi: 10.1093/cid/civ506. Epub 2015 Jun 29.

脑膜炎球菌疫苗接种对带菌和疾病传播的影响：文献综述。

Impact of meningococcal vaccination on carriage and disease transmission: A review of the literature.

机构信息

a Medical Development , Scientific & Clinical Affairs, Pfizer Vaccines, Pfizer Inc , Collegeville , PA , USA.

出版信息

Hum Vaccin Immunother. 2018 May 4;14(5):1118-1130. doi: 10.1080/21645515.2018.1454570. Epub 2018 May 9.

DOI:10.1080/21645515.2018.1454570
PMID:29565712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5989891/
Abstract

Colonization of the human nasopharyngeal tract by the bacterium Neisseria meningitidis is usually asymptomatic, but life-threatening meningococcal disease with a clinical presentation of meningitis, septicemia, or more rarely, gastrointestinal symptoms, can develop. Invasive meningococcal disease (IMD) can be fatal within 24 hours, but IMD is vaccine-preventable. Vaccines used to protect against IMD caused by 5 of the 6 most common serogroups (A, B, C, W, and Y) may also influence carriage prevalence in vaccinated individuals. Lower carriage among vaccinated people may reduce transmission to nonvaccinated individuals to provide herd protection against IMD. This article reviews observational and clinical studies examining effects of vaccination on N. meningitidis carriage prevalence in the context of mass vaccination campaigns and routine immunization programs. Challenges associated with carriage studies are presented alongside considerations for design of future studies to assess the impact of vaccination on carriage.

摘要

人类鼻咽部被脑膜炎奈瑟菌定植通常无症状，但可能会发展为有生命危险的脑膜炎球菌病，表现为脑膜炎、败血症，或更罕见的胃肠道症状。侵袭性脑膜炎球菌病（ IMD ）可在 24 小时内致命，但 IMD 是可通过疫苗预防的。用于预防由 6 种最常见血清群（A、B、C、W 和 Y）中的 5 种引起的 IMD 的疫苗，也可能影响接种者的带菌流行率。接种者的带菌率较低可能会减少对未接种者的传播，从而为 IMD 提供群体保护。本文综述了在大规模疫苗接种运动和常规免疫规划背景下，观察性和临床研究考察疫苗接种对脑膜炎奈瑟菌带菌率的影响。文章还介绍了与带菌研究相关的挑战，并就评估疫苗接种对带菌影响的未来研究设计提出了一些考虑因素。