Korzeniewski K, Skoczyńska A, Guzek A, Konior M, Chciałowski A, Waśko I, Markowska M, Zwolińska E
Department of Epidemiology and Tropical Medicine, Military Institute of Medicine, 4 Grudzińskiego St., Gdynia, 81-103, Poland,
Adv Exp Med Biol. 2015;836:19-28. doi: 10.1007/5584_2014_22.
Neisseria meningitidis, etiological factor of invasive meningococcal disease, is a human commensal that colonizes the nasopharynx. Colonization is usually asymptomatic, but it is a prerequisite for disease. Asymptomatic carriers are the major source of infection. In the present study, a survey of N. meningitidis carriage was conducted between January and March 2013 in a military unit in Poland. Single-time throat culture samples were collected from professional 559 soldiers (302 unvaccinated vs. 257 vaccinated individuals with the quadrivalent conjugate vaccine ACYW-135). Bacterial identification was performed with classic microbiological methods (culture, incubation, identification). Non-culture method (PCR) was used for confirmation of detected strains of N. meningitidis and determination of serogroups. We found 29 carriers in the group of unvaccinated soldiers (9.6 % of examined individuals) whereas among vaccinated soldiers only 3 persons were carriers of N. meningitidis (1.2 %). The most frequently identified serogroups among the carriers serving in the same military facility were serogroup B (28 %), followed by Y (25 %), and C (22 %). In conclusion, the initiation of mass vaccination with the quadrivalent conjugate vaccine ACYW-135 in the military environment seems an effective method of suppressing N. meningitidis carriage.
侵袭性脑膜炎球菌病的病原体脑膜炎奈瑟菌是一种寄居于人类鼻咽部的共生菌。定植通常无症状，但却是发病的先决条件。无症状携带者是主要传染源。在本研究中，于2013年1月至3月在波兰的一个军事单位开展了一项脑膜炎奈瑟菌定植情况调查。从559名职业军人（302名未接种疫苗者与257名接种了四价结合疫苗ACYW-135的接种者）中采集单次咽拭子培养样本。采用经典微生物学方法（培养、孵育、鉴定）进行细菌鉴定。采用非培养方法（PCR）确认检测到的脑膜炎奈瑟菌菌株并确定血清群。我们在未接种疫苗的军人组中发现了29名携带者（占受检个体的9.6%），而在接种疫苗的军人中只有3人是脑膜炎奈瑟菌携带者（1.2%）。在同一军事设施服役的携带者中，最常鉴定出的血清群是B群（28%），其次是Y群（25%）和C群（22%）。总之，在军事环境中启动四价结合疫苗ACYW-135的大规模接种似乎是抑制脑膜炎奈瑟菌定植的有效方法。
