López-Hernández Y, Rivas-Santiago C E, López J A, Mendoza-Almanza G, Hernandez-Pando R
a CONACyT, Unidad Academica de Ciencias Biologicas , Universidad Autónoma de Zacatecas , Zacatecas , Mexico.
b Laboratorio de MicroRNAs, Unidad Academica de Ciencias Biologicas , Universidad Autónoma de Zacatecas , Zacatecas , Mexico.
Exp Lung Res. 2018 Mar;44(2):113-126. doi: 10.1080/01902148.2018.1444824. Epub 2018 Mar 22.
Tuberculosis (TB) has been declared the first cause of death by an infectious agent. Annually, 10.4 million people suffer active TB. Most infected individuals live in low-income countries, where social and economic conditions enhance the dissemination and progression of the disease. These countries have a high percentage of smokers. Thousands of studies have linked cigarette smoke (CS) with increased risk of many diseases, such as cancer and lung diseases. Numerous in vitro studies have been conducted to evaluate the general and specific toxic effects of CS in lung immune function. Smoke exposure increases the risk of TB development three-fold. However, until now, only few animal studies have been performed to analyze the association between smoke and TB. In the present work, we review in vitro and in vivo studies whose aim was to analyze the molecular basis of TB susceptibility caused by exposure to CS.
结核病（TB）已被宣布为由感染因子导致死亡的首要原因。每年有1040万人罹患活动性结核病。大多数感染者生活在低收入国家，那里的社会和经济状况加剧了该疾病的传播和发展。这些国家吸烟者比例很高。数以千计的研究已将香烟烟雾（CS）与许多疾病（如癌症和肺部疾病）风险增加联系起来。已经进行了大量体外研究以评估CS对肺部免疫功能的一般和特定毒性作用。接触烟雾会使结核病发病风险增加两倍。然而，迄今为止，仅开展了少数动物研究来分析烟雾与结核病之间的关联。在本研究中，我们综述了旨在分析接触CS导致结核病易感性的分子基础的体外和体内研究。
