运动功能恢复的截瘫犬的经颅磁运动诱发电位和磁共振成像结果
Transcranial magnetic motor evoked potentials and magnetic resonance imaging findings in paraplegic dogs with recovery of motor function.
作者信息
Siedenburg Johannes S, Wang-Leandro Adriano, Amendt Hanna-Luise, Rohn Karl, Tipold Andrea, Stein Veronika M
机构信息
Division of Neurology, Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.
Institute of Biometry, Epidemiology, and Information Processing, University of Veterinary Medicine Hannover, Hannover, Germany.
出版信息
J Vet Intern Med. 2018 May;32(3):1116-1125. doi: 10.1111/jvim.15058. Epub 2018 Mar 22.
BACKGROUND
Transcranial magnetic motor evoked potentials (TMMEP) are associated with severity of clinical signs and magnetic resonance imaging (MRI) findings in dogs with spinal cord disease.
HYPOTHESIS
That in initially paraplegic dogs with thoracolumbar intervertebral disc herniation (IVDH), MRI findings before surgery and TMMEPs obtained after decompressive surgery are associated with long-term neurological status and correlate with each other.
ANIMALS
Seventeen client-owned paraplegic dogs with acute thoracolumbar IVDH.
METHODS
Prospective observational study. TMMEPs were obtained from pelvic limbs and MRI (3T) of the spinal cord was performed at initial clinical presentation. Follow-up studies were performed ≤ 2 days after reappearance of motor function and 3 months later. Ratios of compression length, intramedullary hyperintensities' length (T2-weighted hyperintensity length ratio [T2WLR]), and lesion extension (T2-weighted-lesion extension ratio) in relation to the length of the 2nd lumbar vertebral body were calculated.
RESULTS
TMMEPs could be elicited in 10/17 (59%) dogs at 1st and in 16/17 (94%) dogs at 2nd follow-up. Comparison of TMMEPs of 1st and 2nd follow-up showed significantly increased amplitudes (median from 0.19 to 0.45 mV) and decreased latencies (from 69.38 to 40.26 ms; P = .01 and .001, respectively). At 2nd follow-up latencies were significantly associated with ambulatory status (P = .024). T2WLR obtained before surgery correlated with latencies at 2nd follow-up (P = .04).
CONCLUSIONS
TMMEP reflect motor function recovery after severe spinal cord injury.
背景
经颅磁运动诱发电位（TMMEP）与脊髓疾病犬的临床体征严重程度及磁共振成像（MRI）结果相关。
假设
在最初截瘫的胸腰椎椎间盘突出症（IVDH）犬中，术前MRI结果和减压手术后获得的TMMEP与长期神经状态相关且相互关联。
动物
17只客户拥有的急性胸腰椎IVDH截瘫犬。
方法
前瞻性观察研究。在初次临床表现时从后肢获取TMMEP，并对脊髓进行MRI（3T）检查。在运动功能再次出现后≤2天及3个月后进行随访研究。计算与第二腰椎椎体长度相关的压迫长度、髓内高信号长度（T2加权高信号长度比[T2WLR]）和病变范围（T2加权病变范围比）的比值。
结果
17只犬中有10只（59%）在第一次随访时可引出TMMEP，16只（94%）在第二次随访时可引出。第一次和第二次随访的TMMEP比较显示，波幅显著增加（中位数从0.19 mV增至0.45 mV），潜伏期缩短（从69.38 ms至40.26 ms；P分别为0.01和0.001）。在第二次随访时，潜伏期与行走状态显著相关（P = 0.024）。术前获得的T2WLR与第二次随访时的潜伏期相关（P = 0.04）。
结论
TMMEP反映严重脊髓损伤后运动功能的恢复。
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