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股骨骨折与输血

Fractures of the femur and blood transfusions.

作者信息

Wertheimer Adam, Olaussen Alexander, Perera Shanaka, Liew Susan, Mitra Biswadev

机构信息

Department of Orthopaedic Surgery, The Alfred Hospital, Australia.

Emergency & Trauma Centre, The Alfred Hospital, Australia; Department of Epidemiology & Preventive Medicine, Monash University, Australia; National Trauma Research Institute, The Alfred Hospital, Australia.

出版信息

Injury. 2018 Apr;49(4):846-851. doi: 10.1016/j.injury.2018.03.007. Epub 2018 Mar 7.

Abstract

BACKGROUND

Blood loss estimation after trauma (i.e. physical injury) and early identification of potential sources of bleeding are important for planning of investigation and management of trauma. Long bone fractures have been reported to be associated with substantial volumes of blood loss requiring blood transfusion. The aim of this study was to assess rates and amounts of blood transfusion in the setting of isolated extra capsular femur fractures and to determine variables associated with the need for transfusion within the first 48 h of admission.

METHODS

A retrospective cohort study was conducted of patients in The Alfred Trauma Registry with isolated extra capsular femur fractures over a 7-year period. We compared patients with a femoral shaft fracture (FSF) to patients with either distal femur or proximal femur fractures (i.e. extremity fracture). We collected data potentially associated with blood transfusion within 48 h as well as operation details and patient outcomes.

RESULTS

There were 293 patients included, of which 121 had FSF and 172 extremity fracture. 105 (36%) patients received a blood transfusion during their admission. Admission haemoglobin (AOR 0.92; 95%CI 0.89-0.94, p < 0.01) was the only independently associated variable with blood transfusion within the first 48 h of hospital admission.

CONCLUSION

Volume of blood transfused to patients with extra-capsular femoral fractures was low and usually in the post-operative period. FSF, compared to femoral extremity fractures, were not more likely to receive blood transfusion within the first 48 h of admission, and did not receive a higher volume of blood overall. In the setting of major trauma with haemorrhagic shock, alternate sources of bleeding should be sought.

摘要

背景

创伤(即身体损伤)后失血的估计以及潜在出血源的早期识别对于创伤的检查和处理规划至关重要。据报道,长骨骨折与大量失血及需要输血有关。本研究的目的是评估单纯股骨颈骨折患者的输血率和输血量,并确定与入院后48小时内输血需求相关的变量。

方法

对阿尔弗雷德创伤登记处7年内患有单纯股骨颈骨折的患者进行了一项回顾性队列研究。我们将股骨干骨折(FSF)患者与股骨远端或近端骨折(即四肢骨折)患者进行了比较。我们收集了48小时内可能与输血相关的数据以及手术细节和患者结局。

结果

共纳入293例患者,其中121例为FSF,172例为四肢骨折。105例(36%)患者在住院期间接受了输血。入院时血红蛋白(调整后比值比0.92;95%置信区间0.89 - 0.94,p < 0.01)是入院后48小时内与输血唯一独立相关的变量。

结论

股骨颈骨折患者的输血量较低,且通常在术后。与四肢骨折相比,FSF在入院后48小时内接受输血的可能性并不更高,总体输血量也没有更多。在伴有失血性休克的重大创伤情况下,应寻找其他出血源。

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