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用于伤口愈合的纳米药物 - 陷入翻译困境?

Nanopharmaceuticals for wound healing - Lost in translation?

机构信息

Department of Pharmaceutical Technology and Nanosciences, Fraunhofer-Institute for Molecular Biology and Applied Ecology (IME), Frankfurt, Germany; Institute of Pharmaceutical Technology, Goethe University, Frankfurt, Germany.

Department of Pharmaceutical Technology and Nanosciences, Fraunhofer-Institute for Molecular Biology and Applied Ecology (IME), Frankfurt, Germany; Institute of Pharmaceutical Technology, Goethe University, Frankfurt, Germany.

出版信息

Adv Drug Deliv Rev. 2018 Apr;129:194-218. doi: 10.1016/j.addr.2018.03.005. Epub 2018 Mar 19.

Abstract

Today, many of the newly developed pharmaceuticals and medical devices take advantage of nanotechnology and with a rising incidence of chronic diseases such as diabetes and cardiovascular disease, the number of patients afflicted globally with non-healing wounds is growing. This has created a requirement for improved therapies and wound care. However, converting the strategies applied in early research into new products is still challenging. Many of them fail to comply with the market requirements. This review discusses the legal and scientific challenges in the design of nanomedicines for wound healing. Are they lost in translation or is there a new generation of therapeutics in the pipeline?

摘要

如今,许多新开发的药品和医疗器械都利用了纳米技术,而且随着糖尿病和心血管疾病等慢性病发病率的上升,在全球范围内患有难以愈合伤口的患者人数正在增加。这就需要改进治疗方法和伤口护理。但是,将早期研究中应用的策略转化为新产品仍然具有挑战性。其中许多产品不符合市场要求。本文讨论了设计用于伤口愈合的纳米药物在法律和科学方面的挑战。是它们在转化中迷失了方向,还是新一代治疗方法即将问世?

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