Anand Murthy S, Krishnamurthy Shantha, Ravindranath Suvarna, Ranganathan Jyothi
Department of Pathology, SRL Reference Lab, Bengaluru, Karnataka, India.
Indian J Pathol Microbiol. 2018 Jan-Mar;61(1):101-102. doi: 10.4103/IJPM.IJPM_659_16.
Merkel cell carcinoma (MCC) is a rare, clinically aggressive neuroendocrine carcinoma of the skin; MCC is 40 times less common as compared to melanoma. The most frequently reported sites have been the head and neck, extremities, and trunk. Potential mimics include malignant melanoma, lymphoma, or metastatic small cell (neuroendocrine) carcinomas. Histopathology of MCC resembles small cell carcinoma both morphologically and on IHC. The possible cell of origin was proposed as the Merkel cell, which functions as a mechanoreceptor. It has a high chance of local recurrence, regional and distant spread. In recent times, Merkel cell polyomavirus has been implicated as the causative agent for this tumor. The same agent has a reported etiologic association with other skin lesions, including seborrheic keratosis.
默克尔细胞癌（MCC）是一种罕见的、临床上具有侵袭性的皮肤神经内分泌癌；与黑色素瘤相比，MCC的发病率要低40倍。最常报道的发病部位是头颈部、四肢和躯干。可能的相似疾病包括恶性黑色素瘤、淋巴瘤或转移性小细胞（神经内分泌）癌。MCC的组织病理学在形态学和免疫组化方面均类似于小细胞癌。其可能的起源细胞被认为是默克尔细胞，它作为一种机械感受器发挥作用。MCC有很高的局部复发、区域和远处转移几率。近年来，默克尔细胞多瘤病毒被认为是这种肿瘤的致病因子。据报道，该病原体与其他皮肤病变包括脂溢性角化病存在病因学关联。
