Caoili Salvador Eugenio
Department of Biochemistry & Molecular Biology, College of Medicine, University of the Philippines Manila, Room 101, Medical Annex Building (Salcedo Hall), 547 Pedro Gil Street, Ermita, Manila 1000, Philippines.
Future Sci OA. 2018 Jan 10;4(3):FSO275. doi: 10.4155/fsoa-2017-0101. eCollection 2018 Mar.
The contemporary Anthropocene is characterized by rapidly evolving complex global challenges to planetary health vis-a-vis sustainable development, yet innovation is constrained under the prevailing precautionary regime that regulates technological change. Small-molecule xenobiotic drugs are amenable to efficient large-scale industrial synthesis; but their pharmacokinetics, pharmacodynamics, interactions and ultimate ecological impact are difficult to predict, raising concerns over initial testing and environmental contamination. Antibodies and similar agents can serve as antidotes and drug buffers or vehicles to address patient safety and decrease dosing requirements. More generally, peptidic agents including synthetic peptide-based constructs exemplified by vaccines can be used together with or instead of nonpeptidic xenobiotics, thus enabling advances in planetary health based on principles of green chemistry from manufacturing through final disposition.
当代人类世的特点是，相对于可持续发展而言，全球对地球健康的复杂挑战迅速演变，但在规范技术变革的现行预防制度下，创新受到限制。小分子外源性药物适合高效大规模工业合成；但其药代动力学、药效学、相互作用及最终的生态影响难以预测，引发了对初始测试和环境污染的担忧。抗体及类似制剂可作为解毒剂、药物缓冲剂或载体，以解决患者安全问题并降低给药需求。更一般地说，包括以疫苗为代表的基于合成肽构建体的肽类制剂可与非肽类外源性物质一起使用或取而代之，从而基于从制造到最终处置的绿色化学原则推动地球健康领域的进步。
