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南非在实现2020年艾滋病毒诊断和抗逆转录病毒治疗目标方面取得的进展。

Progress towards the 2020 targets for HIV diagnosis and antiretroviral treatment in South Africa.

作者信息

Johnson Leigh F, Dorrington Rob E, Moolla Haroon

机构信息

Centre for Infectious Disease Epidemiology and Research, University of Cape Town, South Africa.

Centre for Actuarial Research, University of Cape Town, South Africa.

出版信息

South Afr J HIV Med. 2017 Jul 27;18(1):694. doi: 10.4102/sajhivmed.v18i1.694. eCollection 2017.

Abstract

BACKGROUND

The UNAIDS targets for 2020 are to achieve a 90% rate of diagnosis in HIV-positive individuals, to provide antiretroviral treatment (ART) to 90% of HIV-diagnosed individuals and to achieve virological suppression in 90% of ART patients.

OBJECTIVES

To assess South Africa's progress towards the 2020 targets and variations in performance by province.

METHODS

A mathematical model was fitted to HIV data for each of South Africa's provinces, and for the country as a whole. Numbers of HIV tests performed in each province were estimated from routine data over the 2002-2015 period, and numbers of patients receiving ART in each province were estimated by fitting models to reported public and private ART enrolment statistics.

RESULTS

By the middle of 2015, 85.5% (95% CI: 84.5% - 86.5%) of HIV-positive South African adults had been diagnosed, with little variation between provinces. However, only 56.9% (95% CI: 55.3% - 58.7%) of HIV-diagnosed adults were on ART, with this proportion varying between 50.8% in North West and 72.7% in Northern Cape. In addition, 78.4% of adults on ART were virally suppressed, with rates ranging from 69.7% in Limpopo to 85.9% in Western Cape. Overall, 3.39 million (95% CI: 3.26-3.52 million) South Africans were on ART by mid-2015, equivalent to 48.6% (95% CI: 46.0% - 51.2%) of the HIV-positive population. ART coverage varied between 43.0% in Gauteng and 63.0% in Northern Cape.

CONCLUSION

Although South Africa is well on its way to reaching the 90% HIV diagnosis target, most provinces face challenges in reaching the remaining two 90% targets.

摘要

背景

联合国艾滋病规划署2020年的目标是,使90%的HIV阳性个体得到诊断,为90%已诊断出感染HIV的个体提供抗逆转录病毒治疗(ART),并使90%接受ART治疗的患者实现病毒学抑制。

目的

评估南非在实现2020年目标方面的进展以及各省在执行情况上的差异。

方法

为南非每个省以及整个国家的HIV数据拟合了一个数学模型。根据2002 - 2015年期间的常规数据估算了每个省进行的HIV检测数量,并通过对报告的公共和私人ART登记统计数据拟合模型来估算每个省接受ART治疗的患者数量。

结果

到2015年年中,85.5%(95%置信区间:84.5% - 86.5%)的南非HIV阳性成年人已被诊断出来,各省之间差异不大。然而,只有56.9%(95%置信区间:55.3% - 58.7%)已诊断出感染HIV的成年人正在接受ART治疗,这一比例在西北省为50.8%,在北开普省为72.7%。此外,78.4%接受ART治疗的成年人实现了病毒学抑制,比例从林波波省的69.7%到西开普省的85.9%不等。总体而言,到2015年年中,有339万(95%置信区间:326万 - 352万)南非人正在接受ART治疗,相当于HIV阳性人群的48.6%(95%置信区间:46.0% - 51.2%)。ART覆盖率在豪登省为43.0%,在北开普省为63.0%。

结论

尽管南非在实现90%的HIV诊断目标方面进展顺利,但大多数省份在实现其余两个90%的目标方面面临挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16ab/5843157/b543b17ec1b3/HIVMED-18-694-g001.jpg

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