Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Domžale, 1230, Slovenia.
Epigenomics. 2018 Apr 1;10(4):463-481. doi: 10.2217/epi-2017-0126. Epub 2018 Mar 23.
miRNA regulome is whole set of regulatory elements that regulate miRNA expression or are under control of miRNAs. Its understanding is vital for comprehension of miRNA functions. Classification of miRNA-related genetic variability is challenging because miRNA interact with different genomic elements and are studied at different omics levels. In the present study, miRNA-associated genetic variability is presented at three levels: miRNA genes and their upstream regulation, miRNA silencing machinery and miRNA targets. Several types of miRNA-associated genetic variations are known, including short and structural polymorphisms and epimutations. Differential expression can also affect miRNA regulome function. Classification of miRNA-associated genetic variability presents a baseline for complementing sequence variant nomenclature, planning of experiments, protocols for multi-omics data integration and development of biomarkers.
miRNA 调控组是一套调节 miRNA 表达或受 miRNA 调控的调控元件。理解 miRNA 调控组对于理解 miRNA 的功能至关重要。miRNA 相关遗传变异的分类具有挑战性，因为 miRNA 与不同的基因组元件相互作用，并在不同的组学水平上进行研究。在本研究中，miRNA 相关的遗传变异在三个水平上呈现：miRNA 基因及其上游调控、miRNA 沉默机制和 miRNA 靶标。已知几种类型的 miRNA 相关遗传变异，包括短序列和结构多态性以及表观遗传变异。差异表达也会影响 miRNA 调控组的功能。miRNA 相关遗传变异的分类为补充序列变异命名法、实验设计、多组学数据整合协议和生物标志物的开发提供了基础。
