Nazarenko M S, Koroleva I A, Zarubin A A, Sleptcov A A
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, 634050 Russia.
Siberian State Medical University, Tomsk, 634050 Russia.
Mol Biol (Mosk). 2022 Mar-Apr;56(2):227-243. doi: 10.31857/S0026898422020136.
Dysregulation of microRNA (miRNA) expression is associated with a susceptibility to many diseases, including atherosclerotic lesions of the coronary and carotid arteries and the development of clinical complications such as coronary heart disease, myocardial infarction, chronic cerebral ischemia, ischemic stroke. Recently, more and more studies analyze the miRNA regulome including a network of regulatory elements for the expression of miRNAs themselves and targets under their control. The review summarizes the data from articles concerned miRNA expression and changes in DNA methylation in the miRNA genes in human atherosclerotic arteries, as well as with the analysis of the association between single nucleotide polymorphisms and copy number variations in the miRNA genes with clinical complications of atherosclerosis.
微小RNA（miRNA）表达失调与许多疾病的易感性相关，包括冠状动脉和颈动脉的动脉粥样硬化病变以及冠心病、心肌梗死、慢性脑缺血、缺血性中风等临床并发症的发生。最近，越来越多的研究分析了miRNA调控组，包括miRNA自身表达的调控元件网络及其控制下的靶标。本文综述了有关人类动脉粥样硬化动脉中miRNA表达及miRNA基因DNA甲基化变化的文章数据，以及miRNA基因单核苷酸多态性和拷贝数变异与动脉粥样硬化临床并发症之间关联的分析数据。
