Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Institute of Neuropharmacology, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
J Cosmet Dermatol. 2019 Feb;18(1):55-58. doi: 10.1111/jocd.12529. Epub 2018 Mar 23.
Abobotulinum- toxin A is used extensively for the treatment of frown (glabellar) lines.
The aim of this study was to evaluate the efficacy and complications of a new injection technique and to assess the amount of satisfaction in patients with the frown lines.
This cross-sectional study was conducted in 104 patients with moderate-to-severe glabellar lines. In the new technique by reassessing the responsible anatomic muscles of wrinkles, we tried to modify the injection technique of Abobotulinum-toxin A to yield more favorable results. The range and severity of frown lines were assessed by a 4-score test and a photograph taken before and 2 weeks after the injection. Patients were followed up to 180 days after injection.
The response time of 87.5% of patients was within the first 48 hours and the remaining 12.5% showed the symptoms within the first week after injection. At 30 days after injection, the frown lines had disappeared in 88.5% of patients in static mode and 85.6% in mechanic mode. Maximum injection durability in the first 3, 4, and 6 months after injection was 82%, 52%, and 38%, respectively. The amount of complete satisfaction after 3 months was reported to be 86.5%.
This study indicated that the new injection technique of Abobotulinum-toxin A could be beneficial in the treatment of frown lines with more satisfactory results, especially in those patients who were not contented with the present conventional method.
肉毒毒素 A 被广泛用于治疗皱眉（眉间）纹。
本研究旨在评估一种新的注射技术的疗效和并发症，并评估患者对皱眉线的满意度。
这是一项横断面研究，共纳入 104 例中重度眉间纹患者。在新的技术中，我们重新评估了皱纹的责任解剖肌，试图修改肉毒毒素 A 的注射技术，以获得更理想的效果。使用 4 分制测试和注射前后 2 周的照片评估皱眉线的范围和严重程度。患者在注射后 180 天内接受随访。
87.5%的患者在 48 小时内出现反应，其余 12.5%的患者在注射后第一周内出现症状。在注射后 30 天，88.5%的患者在静态模式下和 85.6%的患者在机械模式下皱眉线消失。注射后 3、4 和 6 个月时的最大注射持续时间分别为 82%、52%和 38%。3 个月后完全满意的比例为 86.5%。
本研究表明，肉毒毒素 A 的新注射技术可能对皱眉线的治疗有益，效果更令人满意，特别是对那些对现有常规方法不满意的患者。
