Zhang Pei-Pei, Ding Da-Zhi, Shi Bing, Zhang Shu-Qing, Gu Ling-Li, Wang Yu-Chan, Cheng Chun
a Department of Immunity, Medical College , Nantong University , Nantong , P. R. China.
b Department of Orthopaedics , Affiliated Hospital of Nantong University , Nantong , Jiangsu , P. R. China.
Leuk Lymphoma. 2018 Nov;59(11):2639-2649. doi: 10.1080/10428194.2018.1452207. Epub 2018 Mar 23.
Tripartite motif containing 28 (TRIM28) as a transcriptional co-repressor has been reported playing a role in regulating DNA damage response (DDR), cell differentiation, immune response, and tumorigenesis. The present study was performed to explore the biological function and clinical significance of TRIM28 in B-cell non-Hodgkin lymphoma (B-NHL). Results of the study displayed that high expression of TRIM28 was positively associated with the poorer survival of B-NHL patients as an independent prognostic factor. In addition, TRIM28 could promote the B-NHL cells proliferation through modulating cell cycle progression. The change of cyclinA, P21, and PCNA expression after TRIM28 expression modified further illustrated the mechanism in which TRIM28 participated in cell proliferation progression. Moreover, inhibition TRIM28 expression in B-NHL cells enhanced the sensibility to Bortezomib by regulating p53-mediated apoptosis pathway. Taken together, the present study showed that TRIM28 functions as a tumor promoter in B-NHL and may be a novel target for drug resistance to Bortezomib.
含28个结构域的三联基序蛋白（TRIM28）作为一种转录共抑制因子，已被报道在调节DNA损伤反应（DDR）、细胞分化、免疫反应和肿瘤发生中发挥作用。本研究旨在探讨TRIM28在B细胞非霍奇金淋巴瘤（B-NHL）中的生物学功能及临床意义。研究结果显示，TRIM28的高表达与B-NHL患者较差的生存率呈正相关，是一个独立的预后因素。此外，TRIM28可通过调节细胞周期进程促进B-NHL细胞增殖。TRIM28表达改变后细胞周期蛋白A、P21和增殖细胞核抗原（PCNA）表达的变化进一步阐明了TRIM28参与细胞增殖进程的机制。此外，抑制B-NHL细胞中TRIM28的表达可通过调节p53介导的凋亡途径增强对硼替佐米的敏感性。综上所述，本研究表明TRIM28在B-NHL中起肿瘤促进作用，可能是硼替佐米耐药的新靶点。
