Yang Yiqing, Tan Shiming, Han Yaqian, Huang Lisheng, Yang Ruiqian, Hu Zifan, Tao Yi, Oyang Linda, Lin Jinguan, Peng Qiu, Jiang Xianjie, Xu Xuemeng, Xia Longzheng, Peng Mingjing, Wu Nayiyuan, Tang Yanyan, Li Xiaoling, Liao Qianjin, Zhou Yujuan
Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
University of South China, Hengyang, Hunan, China.
Front Oncol. 2023 Jan 23;13:1100134. doi: 10.3389/fonc.2023.1100134. eCollection 2023.
Tripartite motif-containing 28 (TRIM28) belongs to tripartite motif (TRIM) family. TRIM28 not only binds and degrades its downstream target, but also acts as a transcription co-factor to inhibit gene expression. More and more studies have shown that TRIM28 plays a vital role in tumor genesis and progression. Here, we reviewed the role of TRIM28 in tumor proliferation, migration, invasion and cell death. Moreover, we also summarized the important role of TRIM28 in tumor stemness sustainability and immune regulation. Because of the importance of TRIM28 in tumors, TIRM28 may be a candidate target for anti-tumor therapy and play an important role in tumor diagnosis and treatment in the future.
含三联基序蛋白28（TRIM28）属于三联基序（TRIM）家族。TRIM28不仅能结合并降解其下游靶点，还可作为转录辅因子抑制基因表达。越来越多的研究表明，TRIM28在肿瘤发生和发展中起着至关重要的作用。在此，我们综述了TRIM28在肿瘤增殖、迁移、侵袭及细胞死亡中的作用。此外，我们还总结了TRIM28在肿瘤干性维持及免疫调节中的重要作用。鉴于TRIM28在肿瘤中的重要性，它可能成为抗肿瘤治疗的候选靶点，并在未来肿瘤诊断和治疗中发挥重要作用。
