FcR+和FcR-单核细胞亚群在体外麻风分枝杆菌诱导的淋巴细胞增殖反应中的调节作用

Regulatory role of FcR+ and FcR- monocyte subsets in Mycobacterium leprae-induced lymphoproliferative response in vitro.

作者信息

Ohkawa S, Martin L N, Fukunishi Y, Gormus B J

出版信息

Clin Exp Immunol. 1987 Jan;67(1):43-50.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1542573/

Abstract

We investigated nine rhesus monkeys (Macaca mulatta) inoculated with Mycobacterium leprae and three normal human contacts. Peripheral blood monocytes were separated into Fc receptor positive (FcR+) and Fc receptor negative (FcR-) fractions, and their regulatory role in the lymphoproliferative response in vitro to M. leprae was studied. FcR- monocytes had strong antigen presentation activity and produced no suppressor effect while FcR+ monocytes had weak antigen presentation activity and produced a non-specific suppressor factor spontaneously. With this assay system we determined that M. leprae-inoculated rhesus monkeys could be divided into three groups: good responders, very weak responders, and non-responders.

摘要

我们研究了9只接种麻风分枝杆菌的恒河猴（猕猴）和3名正常人类接触者。外周血单核细胞被分离为Fc受体阳性（FcR+）和Fc受体阴性（FcR-）组分，并研究了它们在体外对麻风分枝杆菌的淋巴细胞增殖反应中的调节作用。FcR-单核细胞具有较强的抗原呈递活性且不产生抑制作用，而FcR+单核细胞具有较弱的抗原呈递活性并自发产生非特异性抑制因子。通过该检测系统，我们确定接种麻风分枝杆菌的恒河猴可分为三组：良好反应者、非常弱反应者和无反应者。

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Clin Exp Immunol. 1980 Sep;41(3):406-14.

2

Production of a suppressor factor by human adherent cells treated with mycobacteria.经分枝杆菌处理的人黏附细胞产生抑制因子。

J Immunol. 1980 Sep;125(3):1380-6.

3

Monocyte-derived soluble suppressor factor(s) in patients with lepromatous leprosy.瘤型麻风患者单核细胞衍生的可溶性抑制因子

Infect Immun. 1983 Dec;42(3):890-9. doi: 10.1128/iai.42.3.890-899.1983.

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Human dendritic cells. Enrichment and characterization from peripheral blood.人树突状细胞。从外周血中富集与鉴定。

J Exp Med. 1982 Apr 1;155(4):1172-87. doi: 10.1084/jem.155.4.1172.

5

Effect of Mycobacterium leprae on lymphocyte proliferation: suppression of mitogen and antigen responses of human peripheral blood mononuclear cells.麻风分枝杆菌对淋巴细胞增殖的影响：对人外周血单个核细胞有丝分裂原和抗原反应的抑制作用。

Clin Exp Immunol. 1980 Sep;41(3):397-405.

6

Inhibition of interleukin-2 production by adherent cell factors from lepromatous leprosy patients.瘤型麻风患者贴壁细胞因子对白细胞介素-2产生的抑制作用。

Clin Exp Immunol. 1984 Dec;58(3):531-8.

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