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1
Natural suppressor cells in human leprosy: the role of HLA-D-identical peripheral lymphocytes and macrophages in the in vitro modulation of lymphoproliferative responses.人类麻风病中的自然抑制细胞：HLA - D相同的外周淋巴细胞和巨噬细胞在体外调节淋巴细胞增殖反应中的作用。
Clin Exp Immunol. 1980 Nov;42(2):203-10.
2
Genetically restricted suppressor T-cell clones derived from lepromatous leprosy lesions.源自瘤型麻风病损的基因受限抑制性T细胞克隆。
Nature. 1986;322(6078):459-61. doi: 10.1038/322459a0.
3
Evidence for the presence of M. leprae reactive T lymphocytes in patients with lepromatous leprosy.瘤型麻风患者中存在麻风杆菌反应性T淋巴细胞的证据。
Clin Exp Immunol. 1984 Dec;58(3):522-30.
4
The suppressive effect of M. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy.麻风杆菌对麻风病患者淋巴细胞体外增殖反应的抑制作用。
Clin Exp Immunol. 1980 Sep;41(3):406-14.
5
The role of macrophages in the lymphoproliferative response to Mycobacterium leprae in vitro.巨噬细胞在体外对麻风分枝杆菌淋巴增殖反应中的作用。
Clin Exp Immunol. 1978 Oct;34(1):46-51.
6
Cloned suppressor T cells from a lepromatous leprosy patient suppress Mycobacterium leprae reactive helper T cells.从一名瘤型麻风患者身上克隆出的抑制性T细胞可抑制麻风分枝杆菌反应性辅助性T细胞。
Nature. 1986;322(6078):462-4. doi: 10.1038/322462a0.
7
Concanavalin A induced suppressor activity in human leprosy.伴刀豆球蛋白A在人类麻风病中诱导抑制活性。
J Clin Lab Immunol. 1979 Nov;2(4):319-24.
8
In vitro lymphocyte stimulation in patients with lepromatous and borderline tuberculoid leprosy. The effect of dapsone treatment on the response to Mycobacterium leprae antigens, tuberculin purified protein derivative and non-mycobacterial stimulants.瘤型和界线类偏结核样型麻风患者的体外淋巴细胞刺激。氨苯砜治疗对麻风分枝杆菌抗原、结核菌素纯蛋白衍生物及非分枝杆菌刺激物反应的影响。
Int J Lepr Other Mycobact Dis. 1982 Dec;50(4):455-67.
9
Antigen specific macrophage-lymphocyte interaction in lepromatous leprosy.瘤型麻风病中抗原特异性巨噬细胞-淋巴细胞相互作用
J Clin Lab Immunol. 1984 Apr;13(4):189-94.
10
Analysis of cytokine production by Mycobacterium-reactive T cells. Failure to explain Mycobacterium leprae-specific nonresponsiveness of peripheral blood T cells from lepromatous leprosy patients.分枝杆菌反应性T细胞产生细胞因子的分析。未能解释瘤型麻风患者外周血T细胞对麻风分枝杆菌的特异性无反应性。
J Immunol. 1993 May 15;150(10):4641-51.

引用本文的文献

1
Increase in TGF-β secreting CD4⁺CD25⁺ FOXP3⁺ T regulatory cells in anergic lepromatous leprosy patients.无反应性瘤型麻风患者中分泌转化生长因子-β的CD4⁺CD25⁺FOXP3⁺调节性T细胞增加。
PLoS Negl Trop Dis. 2014 Jan 16;8(1):e2639. doi: 10.1371/journal.pntd.0002639. eCollection 2014.
2
Lsr2 peptides of Mycobacterium leprae show hierarchical responses in lymphoproliferative assays, with selective recognition by patients with anergic lepromatous leprosy.麻风分枝杆菌 Lsr2 肽在淋巴增殖试验中表现出层次反应，无反应性瘤型麻风患者具有选择性识别。
Infect Immun. 2012 Feb;80(2):742-52. doi: 10.1128/IAI.05384-11. Epub 2011 Dec 5.
3
Cytokine profile of circulating T cells of leprosy patients reflects both indiscriminate and polarized T-helper subsets: T-helper phenotype is stable and uninfluenced by related antigens of Mycobacterium leprae.麻风病患者循环T细胞的细胞因子谱反映了不加区分和极化的辅助性T细胞亚群：辅助性T细胞表型稳定，不受麻风分枝杆菌相关抗原的影响。
Immunology. 1995 Sep;86(1):97-103.
4
Thymus-dependent lymphocytes in leprosy. II. Effect of chemotherapy on T-lymphocyte subpopulations.麻风病中胸腺依赖淋巴细胞。II. 化疗对T淋巴细胞亚群的影响。
J Clin Immunol. 1982 Apr;2(2):69-74. doi: 10.1007/BF00916889.
5
Prostaglandin-dependent regulation of the in vitro proliferative response to mycobacterial antigens of peripheral blood lymphocytes from normal donors and from patients with tuberculosis or leprosy.前列腺素依赖性调节正常供体以及结核病或麻风病患者外周血淋巴细胞对分枝杆菌抗原的体外增殖反应。
Clin Exp Immunol. 1981 Sep;45(3):646-53.
6
Monocyte-derived soluble suppressor factor(s) in patients with lepromatous leprosy.瘤型麻风患者单核细胞衍生的可溶性抑制因子
Infect Immun. 1983 Dec;42(3):890-9. doi: 10.1128/iai.42.3.890-899.1983.
7
Amyloidosis and the serum amyloid A protein response to muramyl dipeptide analogs and different mycobacterial species.淀粉样变性与血清淀粉样蛋白A对胞壁酰二肽类似物及不同分枝杆菌种类的反应
Infect Immun. 1983 Mar;39(3):1147-54. doi: 10.1128/iai.39.3.1147-1154.1983.
8
Evidence for the presence of M. leprae reactive T lymphocytes in patients with lepromatous leprosy.瘤型麻风患者中存在麻风杆菌反应性T淋巴细胞的证据。
Clin Exp Immunol. 1984 Dec;58(3):522-30.
9
T cell subsets in leprosy lesions: in situ characterization using monoclonal antibodies.麻风病损中的T细胞亚群：使用单克隆抗体的原位特征分析
Clin Exp Immunol. 1983 Mar;51(3):421-9.
10
Inhibition of interleukin-2 production by adherent cell factors from lepromatous leprosy patients.瘤型麻风患者贴壁细胞因子对白细胞介素-2产生的抑制作用。
Clin Exp Immunol. 1984 Dec;58(3):531-8.

本文引用的文献

1
The suppressive effect of M. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy.麻风杆菌对麻风病患者淋巴细胞体外增殖反应的抑制作用。
Clin Exp Immunol. 1980 Sep;41(3):406-14.
2
Reduction of a subset of T cells bearing Fc receptors for IgG in lepromatous leprosy.
Int Arch Allergy Appl Immunol. 1980;62(1):81-5. doi: 10.1159/000232490.
3
Classification of leprosy according to immunity. A five-group system.根据免疫情况对麻风病进行分类。一种五组分类系统。
Int J Lepr Other Mycobact Dis. 1966 Jul-Sep;34(3):255-73.
4
Immunological phenomena in leprosy and related diseases.麻风病及相关疾病中的免疫现象。
Adv Immunol. 1971;13:209-66. doi: 10.1016/s0065-2776(08)60185-6.
5
T cell control of antibody production.T细胞对抗体产生的控制。
Contemp Top Immunobiol. 1974;3:1-40. doi: 10.1007/978-1-4684-3045-5_1.
6
Immune responsiveness to Mycobacterium leprae and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy.在麻风病的整个临床和组织病理学范围内，对麻风分枝杆菌及其他分枝杆菌抗原的免疫反应性。
Clin Exp Immunol. 1973 Aug;14(4):541-53.
7
Inhibition of 3H-thymidine incorporation of lymphocytes by a soluble factor from macrophages.巨噬细胞可溶性因子对淋巴细胞3H-胸腺嘧啶核苷掺入的抑制作用。
Cell Immunol. 1975 Apr;16(2):379-88. doi: 10.1016/0008-8749(75)90126-4.
8
The role of macrophages in the lymphoproliferative response to Mycobacterium leprae in vitro.巨噬细胞在体外对麻风分枝杆菌淋巴增殖反应中的作用。
Clin Exp Immunol. 1978 Oct;34(1):46-51.
9
Immunological aspects of leprosy--present status.
Prog Allergy. 1978;25:211-42.
10
The evolution of immunosuppressive cell populations in experimental mycobacterial infection.实验性分枝杆菌感染中免疫抑制细胞群体的演变
J Immunol. 1978 May;120(5):1709-16.

人类麻风病中的自然抑制细胞：HLA - D相同的外周淋巴细胞和巨噬细胞在体外调节淋巴细胞增殖反应中的作用。

Natural suppressor cells in human leprosy: the role of HLA-D-identical peripheral lymphocytes and macrophages in the in vitro modulation of lymphoproliferative responses.

作者信息

Nath I, Van Rood J J, Mehra N K, Vaidya M C

出版信息

Clin Exp Immunol. 1980 Nov;42(2):203-10.

PMID:6451335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537096/
Abstract

Six families with HLA-D-identical siblings suffering from leprosy were studied. Lymphocytes and macrophages isolated from the peripheral blood were co-cultured with allogeneic, HLA-D-identical cells and stimulated with M. leprae antigens and concanavalin A. Tuberculoid patients had circulating lymphocytes which showed marked functional suppression of lymphoproliferative responses to antigen and mitogen. In contrast, lepromatous patients showed weak lymphocyte suppressor activity. Macrophages derived from responder individuals augmented, while those derived from lepromatous patients inhibited, M. leprae-induced proliferation of lymphocytes.

摘要

对六个有患麻风病的 HLA - D 相同同胞的家庭进行了研究。从外周血中分离出的淋巴细胞和巨噬细胞与 HLA - D 相同的异基因细胞共培养，并用麻风杆菌抗原和刀豆球蛋白 A 刺激。结核样型患者的循环淋巴细胞对抗原和丝裂原的淋巴细胞增殖反应表现出明显的功能抑制。相比之下，瘤型患者的淋巴细胞抑制活性较弱。来自反应者个体的巨噬细胞增强了麻风杆菌诱导的淋巴细胞增殖，而来自瘤型患者的巨噬细胞则抑制了这种增殖。