巨噬细胞在体外对麻风分枝杆菌淋巴增殖反应中的作用。
The role of macrophages in the lymphoproliferative response to Mycobacterium leprae in vitro.
作者信息
Hirschberg H
出版信息
Clin Exp Immunol. 1978 Oct;34(1):46-51.
Abstract
Peripheral blood lymphocytes from patients suffering from lepromatous leprosy do not normally react in vitro to stimulation by Mycobacterium leprae antigens. In contrast, we found that T cells from non-responding patients in combination with macrophages from responding patients or healthy contacts did respond well to M. leprae. Conversely, T cells from responding patients or healthy contacts in combinations with macrophages from non-responding patients failed to respond. It seems, therefore, that the lack of response normally observed in in vitro tests using cells from lepromatous leprosy patients is due to a failure of their macrophages to present M. leprae antigens in an immunogenic form.
摘要
瘤型麻风患者的外周血淋巴细胞通常在体外对麻风杆菌抗原的刺激无反应。相比之下，我们发现无反应患者的T细胞与有反应患者或健康接触者的巨噬细胞联合时，对麻风杆菌有良好反应。相反，有反应患者或健康接触者的T细胞与无反应患者的巨噬细胞联合时则无反应。因此，似乎在使用瘤型麻风患者细胞进行的体外试验中通常观察到的无反应是由于其巨噬细胞未能以免疫原性形式呈递麻风杆菌抗原。
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本文引用的文献
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Are the Ir genes expressed by macrophages?Ir基因是由巨噬细胞表达的吗？
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The interaction of human monocytes and lymphocytes.人类单核细胞与淋巴细胞的相互作用。
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Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes.豚鼠T淋巴细胞抗原识别中巨噬细胞的作用。I. 对组织相容性巨噬细胞和淋巴细胞的需求。
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Antibody-dependent lymphocyte-mediated cytotoxicity in man: no requirement for lymphocytes with membrane-bound immunoglobulin.人抗体依赖性淋巴细胞介导的细胞毒性：无需具有膜结合免疫球蛋白的淋巴细胞。
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Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response.豚鼠T淋巴细胞抗原识别中巨噬细胞的功能。II. 巨噬细胞在免疫反应基因控制调节中的作用。
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