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室间隔心肌切除术联合芬太尼和亚甲蓝治疗后发生血清素综合征:病例报告。

Serotonin Syndrome Following Septal Myectomy in Association With Fentanyl and Methylene Blue: A Case Report.

机构信息

Loyola University Stritch School of Medicine, Maywood, IL.

Loyola University Chicago Stritch School of Medicine, Maywood, IL.

出版信息

Psychosomatics. 2018 Sep-Oct;59(5):512-516. doi: 10.1016/j.psym.2018.02.001. Epub 2018 Feb 13.

DOI:10.1016/j.psym.2018.02.001
PMID:29571985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8383744/
Abstract

The present case report describes a case of serotonin syndrome which developed post-septal myectomy in a patient with hypertrophic cardiomyopathy. This case contributes to an emerging awareness of serotonin syndrome in the context of prescribed serotonergic agents, such as SSRIs, and triggered by the addition of fentanyl and methylene blue, particularly in conjunction cardiological procedures. Clinicians should be aware of such interactions which increase the emergence of the serotonin syndrome and the appropriate management of comorbid delirium post-serotonin syndrome.

摘要

本病例报告描述了一例肥厚型心肌病患者行间隔心肌切除术(septal myectomy)后出现的血清素综合征(serotonin syndrome)。该病例引起了人们对处方中使用血清素能药物(如 SSRIs)以及芬太尼和亚甲蓝(methylene blue)等药物联合使用时出现血清素综合征的关注,尤其是在心脏科手术过程中。临床医生应该注意这些相互作用,这些相互作用会增加血清素综合征的发生,并适当处理血清素综合征后的共病性谵妄。

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Methylene blue-induced serotonin syndrome after left ventricular assist device implantation: A case report and literature review.左心室辅助装置植入术后亚甲蓝诱发的血清素综合征:一例报告及文献综述
J Thorac Cardiovasc Surg. 2017 Sep;154(3):e39-e43. doi: 10.1016/j.jtcvs.2017.05.053. Epub 2017 May 24.
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Serotonin syndrome: Preventing, recognizing, and treating it.血清素综合征:预防、识别与治疗。
Cleve Clin J Med. 2016 Nov;83(11):810-817. doi: 10.3949/ccjm.83a.15129.
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Methylene Blue Causing Serotonin Syndrome Following Cystocele Repair.膀胱膨出修补术后亚甲蓝引发血清素综合征
Urol Case Rep. 2016 Aug 30;9:15-7. doi: 10.1016/j.eucr.2016.07.012. eCollection 2016 Nov.
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Perioperative Diagnosis and Treatment of Serotonin Syndrome Following Administration of Methylene Blue.亚甲蓝给药后血清素综合征的围手术期诊断与治疗
Am J Case Rep. 2016 May 23;17:347-51. doi: 10.12659/ajcr.897671.
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Depressive Symptoms and Risk of Postoperative Delirium.抑郁症状与术后谵妄风险
Am J Geriatr Psychiatry. 2016 Mar;24(3):232-8. doi: 10.1016/j.jagp.2015.12.004. Epub 2016 Feb 17.
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Incidence of serotonin syndrome in patients treated with fentanyl on serotonergic agents.使用芬太尼联合5-羟色胺能药物治疗的患者中血清素综合征的发病率。
Pain Physician. 2015 Jan-Feb;18(1):E27-30.
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Methylene blue and serotonin toxicity: definite causal link.亚甲蓝与5-羟色胺毒性:明确的因果关系。
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