接触化学物质的患者发生进行性系统性硬化症。

Progressive systemic sclerosis occurring in patients exposed to chemicals.

作者信息

Czirják L, Dankó K, Schlammadinger J, Surányi P, Tamási L, Szegedi G Y

出版信息

Int J Dermatol. 1987 Jul-Aug;26(6):374-8. doi: 10.1111/j.1365-4362.1987.tb00565.x.

DOI:10.1111/j.1365-4362.1987.tb00565.x

Abstract

Eight patients with systemic sclerosis previously exposed to organic chemical agents were investigated. Laboratory and clinical data of these patients were evaluated. The interval between the beginning of exposition and symptoms was 6.1 +/- 4.9 years. Considering the laboratory findings, a slight decrease in OKT4 positive T cell number was found. The antinucleolar and fine speckled antinuclear antibody pattern was found simultaneously in five cases. The possible role of chemical agents in the development of sclerodermic changes is discussed.

摘要

对8名曾接触有机化学制剂的系统性硬化症患者进行了调查。对这些患者的实验室和临床数据进行了评估。接触化学制剂开始至出现症状的间隔时间为6.1±4.9年。考虑实验室检查结果，发现OKT4阳性T细胞数量略有减少。在5例患者中同时发现了抗核仁抗体和细颗粒型抗核抗体模式。讨论了化学制剂在硬皮病样改变发生过程中的可能作用。