Department of Development and Regeneration, University of Leuven, Leuven, Belgium.
Department of Development and Regeneration, University of Leuven, Leuven, Belgium; Department of Pediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium.
Matrix Biol. 2018 Aug;68-69:44-66. doi: 10.1016/j.matbio.2018.03.007. Epub 2018 Mar 21.
Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis. Here, we describe the molecular and biological characteristics of CTGF, its regulation and various functions in the spectrum of development and regeneration to fibrosis. We further outline the preclinical and clinical studies concerning compounds targeting CTGF in various pathologies with the focus on heart, lung, liver, kidney and solid organ transplantation. Finally, we address the advances and pitfalls of translational fibrosis research and provide suggestions to move towards a better management of fibrosis.
结缔组织生长因子，又称 CCN2，是一种富含半胱氨酸的基质细胞蛋白，参与控制多种生物学过程，如细胞增殖、分化、黏附和血管生成，以及多种病理过程，如肿瘤发生和组织纤维化。在这里，我们描述了 CTGF 的分子和生物学特征、其调节以及在从发育到纤维化的各种过程中的各种功能。我们进一步概述了针对不同病理情况下 CTGF 的化合物的临床前和临床研究，重点是心脏、肺、肝、肾和实体器官移植。最后，我们讨论了纤维化转化研究的进展和陷阱，并提出了一些建议，以更好地管理纤维化。
