Wärngård L, Flodström S
Department of Toxicology, Karolinska Institute, Stockholm, Sweden.
Cell Biol Toxicol. 1989 Jan;5(1):67-75. doi: 10.1007/BF00141065.
The effects of the pyrethroids flucythrinate, cyfluthrin, bioallethrin and resmethrin on metabolic cooperation between V79 cells were investigated. Addition of flucythrinate to cocultures of 6-thioguanine-resistant and 6-thioguanine-sensitive V79 cells significantly increased the mutant cell recovery, indicating inhibition of intercellular communication. No such effect was observed by the other pyrethroids tested. To compare the modes of action of TPA-, DDT-, and pyrethroid-induced inhibition of intercellular communication, co-exposure experiments were undertaken. Addition of TPA, together with increasing doses of fenvalerate or flucythrinate, produced a synergistic response. Various combinations of fenvalerate-, flucythrinate- and DDT-exposure gave results in accordance with an additive response. The result suggest different pathways of action for TPA and the insecticides investigated in this study.
研究了拟除虫菊酯氟氯氰菊酯、氯氟氰菊酯、生物烯丙菊酯和炔丙菊酯对V79细胞间代谢协同作用的影响。向6-硫鸟嘌呤抗性和6-硫鸟嘌呤敏感的V79细胞共培养物中添加氟氯氰菊酯显著增加了突变细胞的回收率，表明细胞间通讯受到抑制。在所测试的其他拟除虫菊酯中未观察到这种效应。为了比较佛波酯、滴滴涕和拟除虫菊酯诱导的细胞间通讯抑制作用方式，进行了共暴露实验。添加佛波酯以及增加氰戊菊酯或氟氯氰菊酯的剂量会产生协同反应。氰戊菊酯、氟氯氰菊酯和滴滴涕暴露的各种组合产生了符合相加反应的结果。结果表明佛波酯与本研究中所研究的杀虫剂作用途径不同。
