Okine Ayeley A K, Chapman Seth, Hostutler Roger A, Livingston Robert
MedVet Medical and Cancer Center for Pets, Worthington, OH, USA.
Idexx Laboratories, Inc., Worthington, OH, USA.
Vet Clin Pathol. 2018 Mar;47(1):146-149. doi: 10.1111/vcp.12563.
A 2-year-old, female spayed, King Charles Cavalier Spaniel was presented for evaluation of dyspnea, inappetence, and lethargy. Thoracic radiographs revealed a moderate diffuse interstitial lung pattern affecting the perihilar and caudodorsal lung fields, and an echocardiogram revealed severe pulmonary hypertension. A bronchoalveolar lavage (BAL) was performed, and cytology revealed mixed inflammation with cysts and trophozoites consistent with Pneumocystis. Pneumocystis infection was later confirmed with PCR. To the author's knowledge, this report represents the first case of canine pneumocystis pneumonia diagnosed antemortem with PCR from a BAL sample. Pneumocystis represents an important, but uncommon cause of afebrile pneumonia in immunosuppressed dogs.
一只2岁已绝育的雌性查理士王小猎犬因呼吸困难、食欲不振和嗜睡前来接受评估。胸部X光片显示，肺门周围和尾背肺野出现中度弥漫性间质型肺部影像，超声心动图显示严重肺动脉高压。进行了支气管肺泡灌洗（BAL），细胞学检查显示存在混合性炎症，伴有囊肿和滋养体，符合肺孢子虫特征。肺孢子虫感染后来通过聚合酶链反应（PCR）得到确诊。据作者所知，本报告代表了首例通过BAL样本的PCR在生前诊断出犬肺孢子虫肺炎的病例。肺孢子虫是免疫抑制犬非发热性肺炎的一个重要但不常见的病因。
