Alkyl Ethers as Traceless Hydride Donors in Brønsted Acid Catalyzed Intramolecular Hydrogen Atom Transfer.
作者信息
Gandamana Dhika Aditya, Wang Bin, Tejo Ciputra, Bolte Benoit, Gagosz Fabien, Chiba Shunsuke
机构信息
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.
Département de Chimie, UMR 7652 and 7653 CNRS, Ecole Polytechnique, 91128, Palaiseau, France.
出版信息
Angew Chem Int Ed Engl. 2018 May 22;57(21):6181-6185. doi: 10.1002/anie.201801953. Epub 2018 Apr 27.
A new protocol for the deoxygenation of alcohols and the hydrogenation of alkenes under Brønsted acid catalysis has been developed. The method is based on the use of either a benzyl or isopropyl ether as a traceless hydrogen-atom donor, and involves an intramolecular hydride transfer as a key step, which is achieved in a regio- and stereoselective manner.
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