使用苄基醚作为无痕迹氢供体，实现黄原酸盐对烯烃的反马氏加成的氢官能化反应。

Use of a benzyl ether as a traceless hydrogen donor in the anti-Markovnikov hydrofunctionalization of alkenes with xanthates.

机构信息

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.

出版信息

Chem Commun (Camb). 2018 Jul 3;54(54):7535-7538. doi: 10.1039/c8cc02971g.

DOI:10.1039/c8cc02971g

PMID:29926014

Abstract

A new protocol for the anti-Markovnikov hydrofunctionalization of alkenyl alcohol O-Bn ethers was developed using xanthates as functionalizing agents in the presence of lauroyl peroxide as a radical initiator and a stoichiometric oxidant. The benzyl group serves as a traceless hydrogen donor in the remote radical hydrogen atom transfer event during the process.

摘要

开发了一种新的反 Markovnikov 规则的烯基醇 O-Bn 醚的氢官能化方法，使用黄原酸盐作为官能化试剂，在过氧化月桂酰作为自由基引发剂和化学计量氧化剂的存在下进行。在反应过程中，苄基作为远程自由基氢原子转移事件中的无痕迹氢供体。