Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Alberta Transplant Institute, University of Alberta, 6-002 Li Ka Shing Health Research Centre East, Edmonton, Alberta T6G 2E1, Canada.
Trends Immunol. 2018 May;39(5):407-418. doi: 10.1016/j.it.2018.01.008. Epub 2018 Mar 22.
Transplantation outcomes are known to be affected by multiple factors, including donor and recipient sex. Aside from the physiological characteristics of male and female donor allografts, accumulating evidence suggests that additional features underlie sex-specific immune responses that affect graft survival. We discuss here aspects of innate and adaptive alloimmunity that are specific to males and females in the context of underlying genetic and hormonal factors. These differences likely contribute to the observed disparities in graft survival. Understanding these features in more detail may lead to improved strategies for optimizing the results of organ transplantation.
移植的结果受多种因素影响，包括供者和受者的性别。除了男性和女性供者同种异体移植物的生理特征外，越来越多的证据表明，存在其他特征导致了影响移植物存活的特异性免疫反应。本文讨论了在遗传和激素因素背景下男性和女性特有的固有和适应性同种免疫的各个方面。这些差异可能导致观察到的移植物存活率的差异。更详细地了解这些特征可能会导致优化器官移植结果的策略得到改进。
