Martin Friederike, Xiao Yao, Welten Vanessa, Nakamori Keita, Gizlenci Merih, Zhou Hao, Tullius Stefan G
Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Department of Surgery, Campus Charité Mitte|Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Front Transplant. 2024 Jan 9;2:1325232. doi: 10.3389/frtra.2023.1325232. eCollection 2023.
Both age and biological sex affect transplantation outcomes. We have recently shown in a large volume clinical analysis utilizing the SRTR data that graft survival is inferior in young female kidney transplant recipients. In this multi-factorial analysis, older female recipients presented with a trend towards improved transplant outcomes compared to both young female recipients and male recipients of any age. Those data supported by reports of those of others suggest that sex and age impact alloimmune responses both, individually and synergistically. Biological sex and hormone levels change throughout a lifetime with recognized effects on longevity in addition to an impact on the development and course of several disease preconditions. Detailed mechanisms of those sex and age-specific aspects have thus far been studied outside of transplantation. Effects on alloimmunity are largely unknown. Moreover, the combinatorial impact that both, biological sex and age have on transplant outcomes is not understood. Here, we summarize available data that analyze how age in combination with biological sex may shape alloimmune responses and affect transplant outcomes.
年龄和生物性别都会影响移植结果。我们最近在一项利用SRTR数据的大规模临床分析中表明，年轻女性肾移植受者的移植物存活率较低。在这项多因素分析中，与年轻女性受者和任何年龄的男性受者相比，老年女性受者的移植结果有改善的趋势。其他研究报告支持的这些数据表明，性别和年龄分别及协同影响同种免疫反应。生物性别和激素水平在一生中都会发生变化，除了对几种疾病前提条件的发生和发展有影响外，还对寿命有公认的影响。迄今为止，这些性别和年龄特异性方面的详细机制是在移植领域之外进行研究的。对同种免疫的影响在很大程度上尚不清楚。此外，生物性别和年龄对移植结果的综合影响也不为人所知。在此，我们总结了现有数据，这些数据分析了年龄与生物性别相结合如何塑造同种免疫反应并影响移植结果。
